Sequence of the sheep interleukin-10-encoding cDNA

B M Dutia, P Hunt, D R Sargan, R G Dalziel, J Hopkins

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The ovine interleukin-10 (oIL-10)-encoding cDNA has been cloned and sequenced using gene amplification by the polymerase chain reaction (PCR). We present the complete coding sequence of the ovine IL-10 gene, as well as the predicted amino acid (aa) sequence. The oIL10 DNA coding sequence is 531 nucleotides long and the mature protein product is predicted to be 18,367 Da, consisting of 158 aa, excluding a 19-aa N-terminal hydrophobic signal peptide. The oIL-10 protein is > 77% identical to pig and human IL-10, > 71% identical to rodent IL-10 and > 68% identical to viral IL-10.
Original languageEnglish
Pages (from-to)393-4
Number of pages2
Issue number2
Publication statusPublished - 18 Nov 1994

Keywords / Materials (for Non-textual outputs)

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA Primers
  • DNA, Complementary
  • Hominidae
  • Humans
  • Interleukin-10
  • Molecular Sequence Data
  • Open Reading Frames
  • Polymerase Chain Reaction
  • Protein Sorting Signals
  • RNA, Messenger
  • Sequence Homology, Amino Acid
  • Sheep
  • Swine


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