Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Wellcome Trust Case Control Consor; Miles Parkes; Jeffrey C. Barrett; Natalie J. Prescott; Mark Tremelling; Carl A. Anderson; Sheila A. Fisher; Roland G. Roberts; Elaine R. Nimmo; Fraser R. Cummings; Dianne Soars; Hazel Drummond; Charlie W. Lees; Saud A. Khawaja; Richard Bagnall; Denis A. Burke; Catherine E. Todhunter; Tariq Ahmad; Clive M. Onnie; Wendy McArdle; David Strachan; Graeme Bethel; Claire Bryan; Cathryn M. Lewis; Panos Deloukas; Alastair Forbes; Jeremy Sanderson; Derek P. Jewell; Jack Satsangi; John C. Mansfield; Lon Cardon; Christopher G. Mathew

doi:10.1038/ng2061

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Wellcome Trust Case Control Consor, Miles Parkes, Jeffrey C. Barrett, Natalie J. Prescott, Mark Tremelling, Carl A. Anderson, Sheila A. Fisher, Roland G. Roberts, Elaine R. Nimmo, Fraser R. Cummings, Dianne Soars, Hazel Drummond, Charlie W. Lees, Saud A. Khawaja, Richard Bagnall, Denis A. Burke, Catherine E. Todhunter, Tariq Ahmad, Clive M. Onnie, Wendy McArdleDavid Strachan, Graeme Bethel, Claire Bryan, Cathryn M. Lewis, Panos Deloukas, Alastair Forbes, Jeremy Sanderson, Derek P. Jewell, Jack Satsangi, John C. Mansfield, Lon Cardon, Christopher G. Mathew

Research output: Contribution to journal › Article › peer-review

Abstract

A genome- wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

Original language	English
Pages (from-to)	830-832
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	7
DOIs	https://doi.org/10.1038/ng2061
Publication status	Published - Jul 2007

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10.1038/ng2061

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
Published in final edited form as: Nat Genet. 2007 July ; 39(7): 830–832. doi:10.1038/ng2061.
Accepted author manuscript, 103 KB

http://www.nature.com/ng/journal/v39/n7/full/ng2061.html

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Wellcome Trust Case Control Consor, Parkes, M., Barrett, J. C., Prescott, N. J., Tremelling, M., Anderson, C. A., Fisher, S. A., Roberts, R. G., Nimmo, E. R., Cummings, F. R., Soars, D., Drummond, H., Lees, C. W., Khawaja, S. A., Bagnall, R., Burke, D. A., Todhunter, C. E., Ahmad, T., Onnie, C. M., ... Mathew, C. G. (2007). Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nature Genetics, 39(7), 830-832. https://doi.org/10.1038/ng2061

@article{823e396dec46462d953c3185a24cd0af,

title = "Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility",

abstract = "A genome- wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13.",

author = "{Wellcome Trust Case Control Consor} and Miles Parkes and Barrett, {Jeffrey C.} and Prescott, {Natalie J.} and Mark Tremelling and Anderson, {Carl A.} and Fisher, {Sheila A.} and Roberts, {Roland G.} and Nimmo, {Elaine R.} and Cummings, {Fraser R.} and Dianne Soars and Hazel Drummond and Lees, {Charlie W.} and Khawaja, {Saud A.} and Richard Bagnall and Burke, {Denis A.} and Todhunter, {Catherine E.} and Tariq Ahmad and Onnie, {Clive M.} and Wendy McArdle and David Strachan and Graeme Bethel and Claire Bryan and Lewis, {Cathryn M.} and Panos Deloukas and Alastair Forbes and Jeremy Sanderson and Jewell, {Derek P.} and Jack Satsangi and Mansfield, {John C.} and Lon Cardon and Mathew, {Christopher G.}",

year = "2007",

month = jul,

doi = "10.1038/ng2061",

language = "English",

volume = "39",

pages = "830--832",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "7",

}

Wellcome Trust Case Control Consor, Parkes, M, Barrett, JC, Prescott, NJ, Tremelling, M, Anderson, CA, Fisher, SA, Roberts, RG, Nimmo, ER, Cummings, FR, Soars, D, Drummond, H, Lees, CW, Khawaja, SA, Bagnall, R, Burke, DA, Todhunter, CE, Ahmad, T, Onnie, CM, McArdle, W, Strachan, D, Bethel, G, Bryan, C, Lewis, CM, Deloukas, P, Forbes, A, Sanderson, J, Jewell, DP, Satsangi, J, Mansfield, JC, Cardon, L & Mathew, CG 2007, 'Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility', Nature Genetics, vol. 39, no. 7, pp. 830-832. https://doi.org/10.1038/ng2061

TY - JOUR

T1 - Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

AU - Wellcome Trust Case Control Consor

AU - Parkes, Miles

AU - Barrett, Jeffrey C.

AU - Prescott, Natalie J.

AU - Tremelling, Mark

AU - Anderson, Carl A.

AU - Fisher, Sheila A.

AU - Roberts, Roland G.

AU - Nimmo, Elaine R.

AU - Cummings, Fraser R.

AU - Soars, Dianne

AU - Drummond, Hazel

AU - Lees, Charlie W.

AU - Khawaja, Saud A.

AU - Bagnall, Richard

AU - Burke, Denis A.

AU - Todhunter, Catherine E.

AU - Ahmad, Tariq

AU - Onnie, Clive M.

AU - McArdle, Wendy

AU - Strachan, David

AU - Bethel, Graeme

AU - Bryan, Claire

AU - Lewis, Cathryn M.

AU - Deloukas, Panos

AU - Forbes, Alastair

AU - Sanderson, Jeremy

AU - Jewell, Derek P.

AU - Satsangi, Jack

AU - Mansfield, John C.

AU - Cardon, Lon

AU - Mathew, Christopher G.

PY - 2007/7

Y1 - 2007/7

N2 - A genome- wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

AB - A genome- wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

U2 - 10.1038/ng2061

DO - 10.1038/ng2061

M3 - Article

VL - 39

SP - 830

EP - 832

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 7

ER -

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Abstract

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