Seroprevalence of Leptospira hardjo in cattle and African buffalos in southwestern Uganda

Christine Atherstone, Kim Picozzi, Gladys Kalema-Zikusoka

Research output: Contribution to journalArticlepeer-review


Leptospirosis, caused by the spirochete bacterium Leptospira spp. is a zoonosis, distributed worldwide and classified as an emerging infectious disease. Fatal outcomes to leptospiral infection do occur and the disease can cause abortion and other reproductive problems in cattle, goats, and pigs. In humans the symptoms range from subclinical infection to acute febrile illness, pulmonary hemorrhage and renal failure. Leptospirosis has never been officially reported to the World Health Organization (WHO) or the World Animal Health Organization in animals or humans in Uganda. However, favorable ecological conditions and suitable animal hosts can be found within the country. A commercially available enzyme-linked immunosorbent (ELISA) kit was used to screen sera samples from domesticated cattle and African buffalo (Syncerus caffer) at two locations in southwestern Uganda, collected over a 4-year period. Positive samples were found in both cattle and African buffalo samples, from both locations and across the sampling period. Overall seroprevalence was 42.39% in African buffalo and 29.35% in cattle.

Original languageEnglish
Pages (from-to)288-90
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number2
Publication statusPublished - Feb 2014


  • Animals
  • Buffaloes
  • Cattle
  • Cattle Diseases
  • Leptospira
  • Leptospirosis
  • Seroepidemiologic Studies
  • Uganda


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