Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men

A Ratkevicius, A Joyson, I Selmer, T Dhanani, C Grierson, A M Tommasi, A DeVries, P Rauchhaus, D Crowther, S Alesci, P Yaworsky, F Gilbert, T W Redpath, J Brady, K C H Fearon, D M Reid, C A Greig, H Wackerhage, Kenneth Fearon

Research output: Contribution to journalArticlepeer-review

Abstract

Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm(2)) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm(2)) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm(2)), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor α, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p <.001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.
Original languageEnglish
Pages (from-to)620-6
Number of pages7
JournalJournal of Gerontology: Medical Sciences
Volume66
Issue number6
DOIs
Publication statusPublished - 2011

Keywords

  • Adult
  • Aged
  • Follistatin
  • Follistatin-Related Proteins
  • Humans
  • Insulin-Like Growth Factor I
  • Interleukin-6
  • Male
  • Muscle Contraction
  • Myostatin
  • Proteins
  • Sarcopenia
  • Testosterone

Fingerprint Dive into the research topics of 'Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men'. Together they form a unique fingerprint.

Cite this