Serum metabolomic profiles in dogs with chronic enteropathy

Hannah Walker*, Alisdair Boag, Claudia Ottka, Hannes Lohi, Ian Handel, Adam Gow, Richard Mellanby

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background: Metabolic profiles differ between healthy humans and those with inflammatory bowel disease (IBD). Few studies have examined metabolic profiles in dogs with chronic enteropathy (CE).
Hypothesis: Serum metabolic profiles of dogs with CE are significantly different from those of healthy dogs.
Animals: Fifty-five dogs with CE and 204 healthy controls.
Methods: A cross sectional study. The serum concentrations of 99 metabolites measured using a canine-specific proton nuclear magnetic resonance spectroscopy platform were studied. A 2-sample unpaired T test was used to compare the two study samples. The threshold for significance was set at P <0.05 with a Bonferroni correction for each metabolite group.
Results: Nineteen metabolites and 18 indices of lipoprotein composition were significantly different between the CE and healthy dogs. Four metabolites were significantly higher in dogs with CE, including phenylalanine (Mean healthy: 0.0417 mmol/L; standard deviation (SD) healthy 0.0100; Mean CE: 0.0480 mmol/L; SD CE: 0.0125; P Value: < 0.001) and lactate (Mean healthy: 1.8751 mmol/L; SD healthy: 0.7808; Mean CE:2.4827 mmol/L; SD CE: 1.4166; P Value:0.003). Fifteen metabolites were significantly lower in dogs with CE, including the total fatty acids, and the amino acid glycine (Mean healthy:0.2273 mmol/L; SD healthy:0.0794; Mean CE:0.1828 mmol/L; SD CE:0.0517; P Value: < 0.001).
Conclusions and clinical importance: The metabolic profile of dogs with CE is significantly different from that of healthy dogs, this opens novel research avenues to develop better diagnostic and prognostic approaches as well as therapeutic trials.
Original languageEnglish
Pages (from-to)1752-1759
Number of pages8
JournalJournal of Veterinary Internal Medicine
Issue number5
Early online date26 Jul 2022
Publication statusE-pub ahead of print - 26 Jul 2022

Keywords / Materials (for Non-textual outputs)

  • amino acid
  • canine
  • glycoprotein acetyls
  • lipid
  • metabolomics


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