Serum microRNA biomarkers for drug-induced liver injury

P J Starkey Lewis, M Merz, P Couttet, O Grenet, J Dear, D J Antoine, C Goldring, B K Park, J G Moggs

Research output: Contribution to journalArticlepeer-review

Abstract

New biomarkers of drug-induced liver injury (DILI) are required in the clinic and in preclinical pharmaceutical evaluation. Liver-enriched microRNAs are promising serum biomarkers of acetaminophen-induced acute liver injury in mice. The utility of circulating microRNAs as biomarkers of human acute DILI is discussed in the context of correlation with existing biomarkers of liver injury and patient outcomes in acetaminophen toxicity, mechanisms of cellular microRNA release, and their potential advantages over current clinical biomarkers of DILI.

Original languageEnglish
Pages (from-to)291-3
Number of pages3
JournalClinical pharmacology and therapeutics
Volume92
Issue number3
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Animals
  • Biological Markers
  • Drug-Induced Liver Injury
  • Drug-Related Side Effects and Adverse Reactions
  • Humans
  • Liver
  • Mice
  • MicroRNAs

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