Serum neopterin and soluble CD163 as markers of macrophage activation in paracetamol (acetaminophen)-induced human acute liver injury

D. G. Craig; P. Lee; E. A. Pryde; P. C. Hayes; Kenneth Simpson

doi:10.1111/apt.12530

Serum neopterin and soluble CD163 as markers of macrophage activation in paracetamol (acetaminophen)-induced human acute liver injury

D. G. Craig, P. Lee, E. A. Pryde, P. C. Hayes, Kenneth Simpson

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

BackgroundMacrophage activation is implicated in the pathogenesis of the systemic inflammatory response syndrome (SIRS) following paracetamol (acetaminophen) overdose (POD). Neopterin is synthesised from macrophages and reflects the intensity of monocyte/macrophage activation. Soluble CD163 (sCD163) is a marker of alternatively activated M2 macrophages.

AimTo examine neopterin and sCD163 levels in a cohort of acute liver injury patients.

MethodsConsecutive patients (n=41, (18 (43.9%) male) with acute liver injury were enrolled. Neopterin and sCD163 levels were measured by ELISA.

ResultsA total of 24/33 (72.7%) POD patients developed hepatic encephalopathy (HE), and therefore acute liver failure. Both neopterin and sCD163 levels were significantly higher in PODs compared with chronic liver disease (neopterin P

ConclusionsBoth serum neopterin and sCD163 levels are significantly elevated following paracetamol overdose, and reflect the degree of macrophage activation in this condition. Serum neopterin in particular may have value as an early proxy marker of macrophage activation following paracetamol overdose.

Original language	English
Pages (from-to)	1395-1404
Number of pages	10
Journal	Alimentary Pharmacology and Therapeutics
Volume	38
Issue number	11-12
DOIs	https://doi.org/10.1111/apt.12530
Publication status	Published - Dec 2013

Keywords / Materials (for Non-textual outputs)

INFLAMMATORY RESPONSE SYNDROME
ORGAN FAILURE
ACETAMINOPHEN
CYTOKINES
BIOMARKER
SEPSIS

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@article{1405b58d4cc5433db1cecc160f6f3982,

title = "Serum neopterin and soluble CD163 as markers of macrophage activation in paracetamol (acetaminophen)-induced human acute liver injury",

abstract = "BackgroundMacrophage activation is implicated in the pathogenesis of the systemic inflammatory response syndrome (SIRS) following paracetamol (acetaminophen) overdose (POD). Neopterin is synthesised from macrophages and reflects the intensity of monocyte/macrophage activation. Soluble CD163 (sCD163) is a marker of alternatively activated M2 macrophages.AimTo examine neopterin and sCD163 levels in a cohort of acute liver injury patients.MethodsConsecutive patients (n=41, (18 (43.9%) male) with acute liver injury were enrolled. Neopterin and sCD163 levels were measured by ELISA.ResultsA total of 24/33 (72.7%) POD patients developed hepatic encephalopathy (HE), and therefore acute liver failure. Both neopterin and sCD163 levels were significantly higher in PODs compared with chronic liver disease (neopterin PConclusionsBoth serum neopterin and sCD163 levels are significantly elevated following paracetamol overdose, and reflect the degree of macrophage activation in this condition. Serum neopterin in particular may have value as an early proxy marker of macrophage activation following paracetamol overdose.",

keywords = "INFLAMMATORY RESPONSE SYNDROME, ORGAN FAILURE, ACETAMINOPHEN, CYTOKINES, BIOMARKER, SEPSIS",

author = "Craig, {D. G.} and P. Lee and Pryde, {E. A.} and Hayes, {P. C.} and Kenneth Simpson",

year = "2013",

month = dec,

doi = "10.1111/apt.12530",

language = "English",

volume = "38",

pages = "1395--1404",

journal = "Alimentary Pharmacology and Therapeutics",

issn = "0269-2813",

publisher = "Wiley",

number = "11-12",

}

TY - JOUR

T1 - Serum neopterin and soluble CD163 as markers of macrophage activation in paracetamol (acetaminophen)-induced human acute liver injury

AU - Craig, D. G.

AU - Lee, P.

AU - Pryde, E. A.

AU - Hayes, P. C.

AU - Simpson, Kenneth

PY - 2013/12

Y1 - 2013/12

N2 - BackgroundMacrophage activation is implicated in the pathogenesis of the systemic inflammatory response syndrome (SIRS) following paracetamol (acetaminophen) overdose (POD). Neopterin is synthesised from macrophages and reflects the intensity of monocyte/macrophage activation. Soluble CD163 (sCD163) is a marker of alternatively activated M2 macrophages.AimTo examine neopterin and sCD163 levels in a cohort of acute liver injury patients.MethodsConsecutive patients (n=41, (18 (43.9%) male) with acute liver injury were enrolled. Neopterin and sCD163 levels were measured by ELISA.ResultsA total of 24/33 (72.7%) POD patients developed hepatic encephalopathy (HE), and therefore acute liver failure. Both neopterin and sCD163 levels were significantly higher in PODs compared with chronic liver disease (neopterin PConclusionsBoth serum neopterin and sCD163 levels are significantly elevated following paracetamol overdose, and reflect the degree of macrophage activation in this condition. Serum neopterin in particular may have value as an early proxy marker of macrophage activation following paracetamol overdose.

AB - BackgroundMacrophage activation is implicated in the pathogenesis of the systemic inflammatory response syndrome (SIRS) following paracetamol (acetaminophen) overdose (POD). Neopterin is synthesised from macrophages and reflects the intensity of monocyte/macrophage activation. Soluble CD163 (sCD163) is a marker of alternatively activated M2 macrophages.AimTo examine neopterin and sCD163 levels in a cohort of acute liver injury patients.MethodsConsecutive patients (n=41, (18 (43.9%) male) with acute liver injury were enrolled. Neopterin and sCD163 levels were measured by ELISA.ResultsA total of 24/33 (72.7%) POD patients developed hepatic encephalopathy (HE), and therefore acute liver failure. Both neopterin and sCD163 levels were significantly higher in PODs compared with chronic liver disease (neopterin PConclusionsBoth serum neopterin and sCD163 levels are significantly elevated following paracetamol overdose, and reflect the degree of macrophage activation in this condition. Serum neopterin in particular may have value as an early proxy marker of macrophage activation following paracetamol overdose.

KW - INFLAMMATORY RESPONSE SYNDROME

KW - ORGAN FAILURE

KW - ACETAMINOPHEN

KW - CYTOKINES

KW - BIOMARKER

KW - SEPSIS

U2 - 10.1111/apt.12530

DO - 10.1111/apt.12530

M3 - Article

SN - 0269-2813

VL - 38

SP - 1395

EP - 1404

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

IS - 11-12

ER -

Serum neopterin and soluble CD163 as markers of macrophage activation in paracetamol (acetaminophen)-induced human acute liver injury

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Keywords / Materials (for Non-textual outputs)

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