Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD

D A Lomas, E K Silverman, L D Edwards, N W Locantore, B E Miller, D H Horstman, R Tal-Singer, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints study investigators, Bill Macnee

Research output: Contribution to journalArticlepeer-review

Abstract

Surfactant protein (SP)-D is a lung-derived protein that has been proposed as a biomarker for inflammatory lung disease. Serum SP-D was evaluated as a biomarker for components of chronic obstructive pulmonary disease (COPD) in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) cohort and its response assessed to the administration of the anti-inflammatory agent prednisolone. The median level of serum SP-D was significantly elevated in 1,888 individuals with COPD compared to 296 current and former smokers without airflow obstruction (121.1 and 114.3 ng x mL(-1), respectively; p = 0.021) and 201 nonsmokers (82.2 ng x ml(-1); p
Original languageEnglish
Pages (from-to)95-102
Number of pages8
JournalEuropean Respiratory Journal
Volume34
Issue number1
DOIs
Publication statusPublished - 2009

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