Serum urea concentration and the risk of hepatotoxicity after paracetamol overdose

W S Waring, A F L Stephen, O D G Robinson, M A Dow, J M Pettie

Research output: Contribution to journalArticlepeer-review

Abstract

Glutathione depletion increases the incidence of toxicity after paracetamol overdose. Risk factors for toxicity, including chronic ethanol excess and malnutrition, are associated with low serum urea concentrations. Therefore, we hypothesized that low serum urea concentration might itself be predictive of hepatotoxicity in patients that present to hospital after paracetamol overdose.
Original languageEnglish
Pages (from-to)359-63
Number of pages5
JournalQJM: An International Journal of Medicine
Volume101
Issue number5
DOIs
Publication statusPublished - 2008

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