Severe COVID-19 versus multisystem inflammatory syndrome: comparing two critical outcomes of SARS-CoV-2 infection

Rupsha Fraser*, Aurelio Orta-Resendiz, David Dockrell, Michaela Müller-Trutwin, Alexander Mazein

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with diverse host response immunodynamics and variable inflammatory manifestations. Several immune-modulating risk factors can contribute to a more severe coronavirus disease 2019 (COVID-19) course with increased morbidity and mortality. The comparatively rare post-infectious multisystem inflammatory syndrome (MIS) can develop in formerly healthy individuals, with accelerated progression to life-threatening illness. A common trajectory of immune dysregulation forms a continuum of the COVID-19 spectrum and MIS; however, severity of COVID-19 or the development of MIS is dependent on distinct aetiological factors that produce variable host inflammatory responses to infection with different spatiotemporal manifestations, a comprehensive understanding of which is necessary to set better targeted therapeutic and preventative strategies for both.

Original languageEnglish
Article number220197
JournalEuropean Respiratory Review
Volume32
Issue number167
DOIs
Publication statusPublished - 8 Mar 2023

Keywords / Materials (for Non-textual outputs)

  • Humans
  • COVID-19
  • SARS-CoV-2
  • Severity of Illness Index
  • Risk Factors

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