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PNS did not affect social preference in either sex; however social memory was impaired under basal conditions in PNS females, but not PNS males. Accordingly, Avpr1a mRNA expression in the lateral septum and bed nucleus of stria terminalis (BNST) was unaltered in males, but was significantly lower in PNS females, compared with controls. No differences in Oxtr mRNA expression were detected between control and PNS offspring in either sex in any of the brain regions examined. Social memory deficits in PNS females persisted when social odours were used; however this does not appear to be a result of impaired olfaction as memory for non-social odours was similar in control and PNS females.
Under acute stress conditions, deficits in social memory were observed in both male and female control offspring, however PNS males were unaffected. Moreover, acute stress facilitated social memory in PNS females and this was associated with an up-regulation of Avpr1a mRNA in the lateral septum and BNST. Our data support a role for altered signalling via central Avpr1a in PNS-induced sex-dependent changes in social memory and may have implications for understanding the aetiology of neurodevelopmental disorders characterised by social behaviour deficits in humans.
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- 2 Finished
1/09/11 → 30/09/15
Paula Brunton (Invited speaker)6 Jun 2017
Activity: Participating in or organising an event types › Participation in conference