Sex hormone replacement in ovarian failure - New treatment concepts

Jenifer Sassarini, Mary Ann Lumsden, Hilary Critchley

Research output: Contribution to journalBook/Film/Article reviewpeer-review

Abstract / Description of output

Premature ovarian failure is associated with decreased bone mass and fractures, and an increased risk of premature death from cardiovascular disease. There is also fertility compromise associated not only with the loss of ovarian function but, in those with pre-pubertal POF, inadequate uterine morphology. A wide variety of hormone replacement regimes are reported, but there is no clear evidence of best practice. Hormone replacement therapy (HRT) and the combined oral contraceptive pill (COCP) will suppress menopausal symptoms; however neither is designed to achieve physiological replacement of oestrogen and progesterone. There is evidence that physiological sex steroid replacement is superior to standard hormone replacement, in improving uterine volume as well as an improved blood pressure profile and bone mineral density. Sex steroid replacement therapy is long-term in these women, and therefore it is essential that the risk benefit ratio is optimal to maximise longer term health.
Original languageEnglish
Pages (from-to)105-114
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Issue number1
Early online date2 Oct 2014
Publication statusPublished - Jan 2015


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