Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

DIAGRAM Consortium; Joshua C Randall; Thomas W Winkler; Zoltán Kutalik; Sonja I Berndt; Anne U Jackson; Keri L Monda; Tuomas O Kilpeläinen; Tõnu Esko; Reedik Mägi; Shengxu Li; Tsegaselassie Workalemahu; Mary F Feitosa; Damien C Croteau-Chonka; Felix R Day; Tove Fall; Teresa Ferreira; Stefan Gustafsson; Adam E Locke; Iain Mathieson; Andre Scherag; Sailaja Vedantam; Andrew R Wood; Liming Liang; Valgerdur Steinthorsdottir; Gudmar Thorleifsson; Emmanouil T Dermitzakis; Antigone S Dimas; Fredrik Karpe; Josine L Min; George Nicholson; Deborah J Clegg; Thomas Person; Jon P Krohn; Sabrina Bauer; Christa Buechler; Kristina Eisinger; Amélie Bonnefond; Philippe Froguel; Jouke-Jan Hottenga; Inga Prokopenko; Lindsay L Waite; Tamara B Harris; Harry Campbell; James F Wilson; Caroline Hayward; Igor Rudan; Jennifer L Bolton; Gerry Fowkes; Ross M Fraser; Jackie F Price

doi:10.1371/journal.pgen.1003500

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

DIAGRAM Consortium, Joshua C Randall, Thomas W Winkler, Zoltán Kutalik, Sonja I Berndt, Anne U Jackson, Keri L Monda, Tuomas O Kilpeläinen, Tõnu Esko, Reedik Mägi, Shengxu Li, Tsegaselassie Workalemahu, Mary F Feitosa, Damien C Croteau-Chonka, Felix R Day, Tove Fall, Teresa Ferreira, Stefan Gustafsson, Adam E Locke, Iain MathiesonAndre Scherag, Sailaja Vedantam, Andrew R Wood, Liming Liang, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Emmanouil T Dermitzakis, Antigone S Dimas, Fredrik Karpe, Josine L Min, George Nicholson, Deborah J Clegg, Thomas Person, Jon P Krohn, Sabrina Bauer, Christa Buechler, Kristina Eisinger, Amélie Bonnefond, Philippe Froguel, Jouke-Jan Hottenga, Inga Prokopenko, Lindsay L Waite, Tamara B Harris, Harry Campbell, James F Wilson, Caroline Hayward, Igor Rudan, Jennifer L Bolton, Gerry Fowkes, Ross M Fraser, Jackie F Price

Research output: Contribution to journal › Article › peer-review

Abstract

Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR

Original language	English
Article number	e1003500
Number of pages	19
Journal	PLoS Genetics
Volume	9
Issue number	6
DOIs	https://doi.org/10.1371/journal.pgen.1003500
Publication status	Published - Jun 2013

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10.1371/journal.pgen.1003500

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
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DIAGRAM Consortium, Randall, J. C., Winkler, T. W., Kutalik, Z., Berndt, S. I., Jackson, A. U., Monda, K. L., Kilpeläinen, T. O., Esko, T., Mägi, R., Li, S., Workalemahu, T., Feitosa, M. F., Croteau-Chonka, D. C., Day, F. R., Fall, T., Ferreira, T., Gustafsson, S., Locke, A. E., ... Price, J. F. (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genetics, 9(6), Article e1003500. https://doi.org/10.1371/journal.pgen.1003500

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title = "Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits",

abstract = "Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR",

author = "\{DIAGRAM Consortium\} and Randall, \{Joshua C\} and Winkler, \{Thomas W\} and Zolt{\'a}n Kutalik and Berndt, \{Sonja I\} and Jackson, \{Anne U\} and Monda, \{Keri L\} and Kilpel{\"a}inen, \{Tuomas O\} and T{\~o}nu Esko and Reedik M{\"a}gi and Shengxu Li and Tsegaselassie Workalemahu and Feitosa, \{Mary F\} and Croteau-Chonka, \{Damien C\} and Day, \{Felix R\} and Tove Fall and Teresa Ferreira and Stefan Gustafsson and Locke, \{Adam E\} and Iain Mathieson and Andre Scherag and Sailaja Vedantam and Wood, \{Andrew R\} and Liming Liang and Valgerdur Steinthorsdottir and Gudmar Thorleifsson and Dermitzakis, \{Emmanouil T\} and Dimas, \{Antigone S\} and Fredrik Karpe and Min, \{Josine L\} and George Nicholson and Clegg, \{Deborah J\} and Thomas Person and Krohn, \{Jon P\} and Sabrina Bauer and Christa Buechler and Kristina Eisinger and Am{\'e}lie Bonnefond and Philippe Froguel and Jouke-Jan Hottenga and Inga Prokopenko and Waite, \{Lindsay L\} and Harris, \{Tamara B\} and Harry Campbell and Wilson, \{James F\} and Caroline Hayward and Igor Rudan and Bolton, \{Jennifer L\} and Gerry Fowkes and Fraser, \{Ross M\} and Price, \{Jackie F\}",

note = "MRC and Wellcome Trust funding",

year = "2013",

month = jun,

doi = "10.1371/journal.pgen.1003500",

language = "English",

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DIAGRAM Consortium, Randall, JC, Winkler, TW, Kutalik, Z, Berndt, SI, Jackson, AU, Monda, KL, Kilpeläinen, TO, Esko, T, Mägi, R, Li, S, Workalemahu, T, Feitosa, MF, Croteau-Chonka, DC, Day, FR, Fall, T, Ferreira, T, Gustafsson, S, Locke, AE, Mathieson, I, Scherag, A, Vedantam, S, Wood, AR, Liang, L, Steinthorsdottir, V, Thorleifsson, G, Dermitzakis, ET, Dimas, AS, Karpe, F, Min, JL, Nicholson, G, Clegg, DJ, Person, T, Krohn, JP, Bauer, S, Buechler, C, Eisinger, K, Bonnefond, A, Froguel, P, Hottenga, J-J, Prokopenko, I, Waite, LL, Harris, TB, Campbell, H , Wilson, JF , Hayward, C , Rudan, I, Bolton, JL, Fowkes, G, Fraser, RM & Price, JF 2013, 'Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits', PLoS Genetics, vol. 9, no. 6, e1003500. https://doi.org/10.1371/journal.pgen.1003500

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AU - DIAGRAM Consortium

AU - Randall, Joshua C

AU - Winkler, Thomas W

AU - Kutalik, Zoltán

AU - Berndt, Sonja I

AU - Jackson, Anne U

AU - Monda, Keri L

AU - Kilpeläinen, Tuomas O

AU - Esko, Tõnu

AU - Mägi, Reedik

AU - Li, Shengxu

AU - Workalemahu, Tsegaselassie

AU - Feitosa, Mary F

AU - Croteau-Chonka, Damien C

AU - Day, Felix R

AU - Fall, Tove

AU - Ferreira, Teresa

AU - Gustafsson, Stefan

AU - Locke, Adam E

AU - Mathieson, Iain

AU - Scherag, Andre

AU - Vedantam, Sailaja

AU - Wood, Andrew R

AU - Liang, Liming

AU - Steinthorsdottir, Valgerdur

AU - Thorleifsson, Gudmar

AU - Dermitzakis, Emmanouil T

AU - Dimas, Antigone S

AU - Karpe, Fredrik

AU - Min, Josine L

AU - Nicholson, George

AU - Clegg, Deborah J

AU - Person, Thomas

AU - Krohn, Jon P

AU - Bauer, Sabrina

AU - Buechler, Christa

AU - Eisinger, Kristina

AU - Bonnefond, Amélie

AU - Froguel, Philippe

AU - Hottenga, Jouke-Jan

AU - Prokopenko, Inga

AU - Waite, Lindsay L

AU - Harris, Tamara B

AU - Campbell, Harry

AU - Wilson, James F

AU - Hayward, Caroline

AU - Rudan, Igor

AU - Bolton, Jennifer L

AU - Fowkes, Gerry

AU - Fraser, Ross M

AU - Price, Jackie F

N1 - MRC and Wellcome Trust funding

PY - 2013/6

Y1 - 2013/6

N2 - Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR

AB - Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR

U2 - 10.1371/journal.pgen.1003500

DO - 10.1371/journal.pgen.1003500

M3 - Article

C2 - 23754948

SN - 1553-7390

VL - 9

JO - PLoS Genetics

JF - PLoS Genetics

IS - 6

M1 - e1003500

ER -

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Abstract

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