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Abstract / Description of output
The 18 kDa translocator protein is a well-known biomarker of neuroinflammation, but also plays a role in homeostasis. PET with 18 kDa translocator protein radiotracers [11C]PBR28 in humans and [18F]GE180 in mice has demonstrated sex-dependent uptake patterns in the healthy brain, suggesting sex-dependent 18 kDa translocator protein expression, although humans and mice had differing results. This study aimed to assess whether the 18 kDa translocator protein PET radiotracer [18F]LW223 exhibited sexually dimorphic uptake in healthy murine brain and peripheral organs. Male and female C57Bl6/J mice (13.6 ± 5.4 weeks, 26.8 ± 5.4 g, mean ± SD) underwent 2 h PET scanning post-administration of [18F]LW223 (6.7 ± 3.6 MBq). Volume of interest and parametric analyses were performed using standard uptake values (90–120 min). Statistical differences were assessed by unpaired t-test or two-way ANOVA with Šidak’s test (alpha = 0.05). The uptake of [18F]LW223 was significantly higher across multiple regions of the male mouse brain, with the most pronounced difference detected in hypothalamus (P < 0.0001). Males also exhibited significantly higher [18F]LW223 uptake in the heart when compared to females (P = 0.0107). Data support previous findings on sexually dimorphic 18 kDa translocator protein radiotracer uptake patterns in mice and highlight the need to conduct sex-controlled comparisons in 18 kDa translocator protein PET imaging studies.
Original language | English |
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Journal | Brain Communications |
Volume | 6 |
Issue number | 1 |
DOIs | |
Publication status | Published - 16 Jan 2024 |
Keywords / Materials (for Non-textual outputs)
- TSPO
- PET
- [18F]LW223
- sex differences
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Myocardial Fibrosis And Left Ventricular Remodelling In Cardiovascular Disease
Tavares, A., Baker, A. & Newby, D.
1/10/19 → 30/09/24
Project: Research
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Datasets
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Sexually dimorphic murine brain uptake of the 18 kDa translocator protein PET radiotracer [18F]LW223
Alcaide Corral, C. (Creator), Sutherland, A. (Creator), Tavares, A. (Creator), Knyzeliene, A. (Creator), Wimberley, C. (Creator), Macaskill, M. (Creator), Morgan, T. E. (Creator), Henry, M. C. (Creator), Lucatelli, C. (Creator) & Pimlott, S. L. (Creator), Edinburgh DataShare, 3 Apr 2024
DOI: 10.7488/ds/7715
Dataset