Shape regulated anticancer activities and systematic toxicities of drug nanocrystals in vivo

Mengjiao Zhou, Xiujuan Zhang, Caitong Yu, Xueyan Nan, Xianfeng Chen, Xiaohong Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper, shape regulated anticancer activities as well as systematic toxicities of hydroxycamptothecin nanorods and nanoparticles (HCPT NRs and NPs) were systematically studied. In vitro and in vivo therapeutic efficacies were evaluated in cancer cells and tumorbearing mice, indicating that NRs possessed superior antitumor efficacy over NPs at the equivalent dose, while systematic toxicity of the differently shaped nanodrugs assessed in healthy mice, including the maximum tolerated dose, blood analysis and histology examinations and so on, suggested that the NRs also caused higher toxicities than NPs, and also had a long-term toxicity. These results imply that the balance between anticancer efficiency and systematic toxicity of drug nanocrystals should be fully considered in practice, which will provide new concept in the future design of drug nanocrystals for cancer therapy.
Original languageEnglish
Pages (from-to)181-189
JournalNanomedicine: Nanotechnology, Biology and Medicine
Volume12
Early online date30 Sep 2015
DOIs
Publication statusPublished - Jan 2016

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