Shared lesion correlates of semantic and letter fluency in post-stroke aphasia

Melissa Thye*, Jerzy P. Szaflarski, Daniel Mirman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Lesion–symptom mapping studies have reported a temporal versus frontal dissociation between semantic and letter fluency, and mixed evidence regarding the role of white matter. Mass-univariate and multivariate lesion–symptom mapping was used to identify regions associated with semantic and letter fluency deficits in post-stroke aphasia. Multivariate LSM revealed broad networks including underlying white matter, and substantial overlap between both types of fluency, suggesting that semantic fluency and letter fluency largely rely on the same neural system. All data are available on OSF.
Original languageEnglish
JournalJournal of Neuropsychology
Early online date15 May 2020
Publication statusE-pub ahead of print - 15 May 2020

Keywords / Materials (for Non-textual outputs)

  • aphasia
  • lesion-symptom mapping
  • sparse canonical correlation analysis
  • verbal fluency


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