Shining a light on the dark secrets of the cell: Synthetic proteins for better fluorescence imaging

Lynne Regan, Curran Oi, Diana Tokarska

Research output: Contribution to journalReview articlepeer-review

Abstract

The discovery of intrinsically fluorescent proteins revolutionized our ability to visualize proteins within living cells. Since that original observation, a plethora of fluorescent proteins with varied colour and brightness have been obtained. For a number of imaging purposes, however, synthetic biology approaches have been required to create new labelling methodologies. Here, we describe the protein engineering technologies that underlie some of those key designs and show how they have been used to great effect in different cell types.
Original languageEnglish
Pages (from-to)40-46
JournalThe Biochemist
Volume41
DOIs
Publication statusPublished - 30 Jun 2019

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