TY - GEN
T1 - Shock-induced arrhythmogenesis in the human heart
T2 - A computational modelling study
AU - Bernabeu, Miguel O
AU - Wallman, Mikael
AU - Rodriguez, Blanca
PY - 2010/11/11
Y1 - 2010/11/11
N2 - Electrical defibrillation by application of a strong shock to the heart is the only effective treatment against lethal cardiac arrhythmias such as ventricular fibrillation. A large body of experimental and computational research has been devoted to understanding shock-induced effects on the heart in an attempt to improve defibrillation efficacy. However, most of the research has been performed in small animal hearts, and in particular rabbits. The difference in size between rabbits and humans might limit the extrapolation of the results to the clinical setting. In this paper, we present, for the first time, computer simulations of shock-induced effects on a human ventricular model with realistic ion channel dynamics and fibre architecture. Bidomain simulations using the human ventricular model were performed using the Chaste open source simulation package. The parallel performance of the software package was highly improved in order to meet the computational requirements of these kind of studies.
AB - Electrical defibrillation by application of a strong shock to the heart is the only effective treatment against lethal cardiac arrhythmias such as ventricular fibrillation. A large body of experimental and computational research has been devoted to understanding shock-induced effects on the heart in an attempt to improve defibrillation efficacy. However, most of the research has been performed in small animal hearts, and in particular rabbits. The difference in size between rabbits and humans might limit the extrapolation of the results to the clinical setting. In this paper, we present, for the first time, computer simulations of shock-induced effects on a human ventricular model with realistic ion channel dynamics and fibre architecture. Bidomain simulations using the human ventricular model were performed using the Chaste open source simulation package. The parallel performance of the software package was highly improved in order to meet the computational requirements of these kind of studies.
KW - Action Potentials
KW - Arrhythmias, Cardiac
KW - Computer Simulation
KW - Electric Stimulation
KW - Electromagnetic Fields
KW - Heart Conduction System
KW - Humans
KW - Models, Cardiovascular
U2 - 10.1109/IEMBS.2010.5626338
DO - 10.1109/IEMBS.2010.5626338
M3 - Conference contribution
C2 - 21095904
SN - 978-1-4244-4123-5
SP - 760
EP - 763
BT - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology
ER -