Short TE quantitative proton magnetic resonance spectroscopy in variant Creutzfeldt-Jakob disease

R J Cordery, D MacManus, A Godbolt, M N Rossor, A D Waldman

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegenerative disorder. Clinical diagnosis is difficult in the early stages as the disease often presents with non-specific psychiatric and neurological symptoms. To investigate the diagnostic potential of quantitative short TE in vivo MRS, and the nature and anatomical distribution of biochemical abnormalities in vCJD, localised single-voxel spectra (TE/TR 30 ms/2,000 ms) were acquired from three brain regions: thalami, caudate nuclei and frontal white matter. Metabolite concentrations and ratios from three patients with definite or probable vCJD were compared with eight normal age-matched controls. Abnormal signal on T2-weighted MRI was apparent in the pulvinar region in all vCJD patients; this region also showed greatly increased myo-inositol [MI] (mean 2.5-fold, P=0.01) and decreased N-acetyl-aspartate (NAA; mean 2-fold, P=0.01). Two patients also showed increased [MI] (z=17, 11; one with decreased NAA, z=-12) in normal-appearing caudate nuclei. The magnitude of metabolite abnormalities in the thalami in moderately advanced vCJD suggests a potential role in earlier diagnosis. Short TE protocols allow the measurement of MI, which adds discriminant power to the MRS examination.

Original languageEnglish
Pages (from-to)1692-8
Number of pages7
JournalEuropean Radiology
Issue number8
Publication statusPublished - 12 Jan 2006

Keywords / Materials (for Non-textual outputs)

  • Adult
  • Aspartic Acid
  • Case-Control Studies
  • Choline
  • Creatine
  • Creutzfeldt-Jakob Syndrome
  • Female
  • Glutamic Acid
  • Humans
  • Inositol
  • Magnetic Resonance Spectroscopy
  • Male
  • Phosphocreatine
  • Protons
  • Statistics, Nonparametric
  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't


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