Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension

Lauren Brash; Gareth D. Barnes; Melanie J. Brewis; A. Colin Church; Simon J. Gibbs; Luke S.G.E. Howard; Geeshath Jayasekera; Martin K. Johnson; Neil McGlinchey; Joelle Onorato; Joanne Simpson; Colin Stirrat; Stephen Thomson; Geoffrey Watson; Martin R. Wilkins; Carrie Xu; David J. Welsh; David E. Newby; Andrew J. Peacock

doi:10.1016/j.jacbts.2018.01.013

Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension

Lauren Brash, Gareth D. Barnes, Melanie J. Brewis, A. Colin Church, Simon J. Gibbs, Luke S.G.E. Howard, Geeshath Jayasekera, Martin K. Johnson, Neil McGlinchey, Joelle Onorato, Joanne Simpson, Colin Stirrat, Stephen Thomson, Geoffrey Watson, Martin R. Wilkins, Carrie Xu, David J. Welsh, David E. Newby, Andrew J. Peacock^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic apelin infusion in patients with PAH. In a double-blind randomized crossover study, 19 patients with PAH received intravenous (Pyr¹)apelin-13 and matched saline placebo during invasive right heart catheterization. (Pyr¹)apelin-13 infusion caused a reduction in pulmonary vascular resistance and increased cardiac output. This effect was accentuated in the subgroup of patients receiving concomitant phosphodiesterase type 5 inhibition. Apelin agonism is a novel potential therapeutic target for PAH. (Effects of Apelin on the Lung Circulation in Pulmonary Hypertension; NCT01457170)

Original language	English
Pages (from-to)	176-186
Number of pages	11
Journal	JACC: Basic to Translational Science
Volume	3
Issue number	2
Early online date	28 Mar 2018
DOIs	https://doi.org/10.1016/j.jacbts.2018.01.013
Publication status	E-pub ahead of print - 28 Mar 2018

Keywords / Materials (for Non-textual outputs)

apelin
APJ
human
pulmonary arterial hypertension

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10.1016/j.jacbts.2018.01.013

1-s2.0-S2452302X18300561-mainProof, 1.16 MBLicence: CC BY-NC-ND

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Brash, L., Barnes, G. D., Brewis, M. J., Church, A. C., Gibbs, S. J., Howard, L. S. G. E., Jayasekera, G., Johnson, M. K., McGlinchey, N., Onorato, J., Simpson, J., Stirrat, C., Thomson, S., Watson, G., Wilkins, M. R., Xu, C., Welsh, D. J., Newby, D. E., & Peacock, A. J. (2018). Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension. JACC: Basic to Translational Science, 3(2), 176-186. Advance online publication. https://doi.org/10.1016/j.jacbts.2018.01.013

@article{9c35a9e1ea53472ebe3cd48097b91623,

title = "Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension",

abstract = "Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic apelin infusion in patients with PAH. In a double-blind randomized crossover study, 19 patients with PAH received intravenous (Pyr1)apelin-13 and matched saline placebo during invasive right heart catheterization. (Pyr1)apelin-13 infusion caused a reduction in pulmonary vascular resistance and increased cardiac output. This effect was accentuated in the subgroup of patients receiving concomitant phosphodiesterase type 5 inhibition. Apelin agonism is a novel potential therapeutic target for PAH. (Effects of Apelin on the Lung Circulation in Pulmonary Hypertension; NCT01457170)",

keywords = "apelin, APJ, human, pulmonary arterial hypertension",

author = "Lauren Brash and Barnes, {Gareth D.} and Brewis, {Melanie J.} and Church, {A. Colin} and Gibbs, {Simon J.} and Howard, {Luke S.G.E.} and Geeshath Jayasekera and Johnson, {Martin K.} and Neil McGlinchey and Joelle Onorato and Joanne Simpson and Colin Stirrat and Stephen Thomson and Geoffrey Watson and Wilkins, {Martin R.} and Carrie Xu and Welsh, {David J.} and Newby, {David E.} and Peacock, {Andrew J.}",

year = "2018",

month = mar,

day = "28",

doi = "10.1016/j.jacbts.2018.01.013",

language = "English",

volume = "3",

pages = "176--186",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

publisher = "Elsevier",

number = "2",

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Brash, L, Barnes, GD, Brewis, MJ, Church, AC, Gibbs, SJ, Howard, LSGE, Jayasekera, G, Johnson, MK, McGlinchey, N, Onorato, J, Simpson, J , Stirrat, C, Thomson, S, Watson, G, Wilkins, MR, Xu, C, Welsh, DJ, Newby, DE & Peacock, AJ 2018, 'Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension', JACC: Basic to Translational Science, vol. 3, no. 2, pp. 176-186. https://doi.org/10.1016/j.jacbts.2018.01.013

TY - JOUR

T1 - Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension

AU - Brash, Lauren

AU - Barnes, Gareth D.

AU - Brewis, Melanie J.

AU - Church, A. Colin

AU - Gibbs, Simon J.

AU - Howard, Luke S.G.E.

AU - Jayasekera, Geeshath

AU - Johnson, Martin K.

AU - McGlinchey, Neil

AU - Onorato, Joelle

AU - Simpson, Joanne

AU - Stirrat, Colin

AU - Thomson, Stephen

AU - Watson, Geoffrey

AU - Wilkins, Martin R.

AU - Xu, Carrie

AU - Welsh, David J.

AU - Newby, David E.

AU - Peacock, Andrew J.

PY - 2018/3/28

Y1 - 2018/3/28

N2 - Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic apelin infusion in patients with PAH. In a double-blind randomized crossover study, 19 patients with PAH received intravenous (Pyr1)apelin-13 and matched saline placebo during invasive right heart catheterization. (Pyr1)apelin-13 infusion caused a reduction in pulmonary vascular resistance and increased cardiac output. This effect was accentuated in the subgroup of patients receiving concomitant phosphodiesterase type 5 inhibition. Apelin agonism is a novel potential therapeutic target for PAH. (Effects of Apelin on the Lung Circulation in Pulmonary Hypertension; NCT01457170)

AB - Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic apelin infusion in patients with PAH. In a double-blind randomized crossover study, 19 patients with PAH received intravenous (Pyr1)apelin-13 and matched saline placebo during invasive right heart catheterization. (Pyr1)apelin-13 infusion caused a reduction in pulmonary vascular resistance and increased cardiac output. This effect was accentuated in the subgroup of patients receiving concomitant phosphodiesterase type 5 inhibition. Apelin agonism is a novel potential therapeutic target for PAH. (Effects of Apelin on the Lung Circulation in Pulmonary Hypertension; NCT01457170)

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KW - APJ

KW - human

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DO - 10.1016/j.jacbts.2018.01.013

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JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

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ER -

Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension

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The BHF Chair of Cardiology

Identification and prediction of coronary artery plaque rupture using 18F-fluoride positron emission tomography

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Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension

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The BHF Chair of Cardiology

Identification and prediction of coronary artery plaque rupture using 18F-fluoride positron emission tomography

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