Short-term telomere dynamics is associated with glucocorticoid levels in wild populations of roe deer

Jean-François Lemaître; Jeffrey Carbillet; Benjamin Rey; Rupert Palme; Hannah Froy; Rachael V. Wilbourn; Sarah L. Underwood; Louise Cheynel; Jean-Michel Gaillard; A.J. Mark Hewison; Hélène Verheyden; François Débias; Jeanne Duhayer; Corinne Régis; Sylvia Pardonnet; Maryline Pellerin; Daniel H. Nussey; Emmanuelle Gilot-Fromont

doi:10.1016/j.cbpa.2020.110836

Short-term telomere dynamics is associated with glucocorticoid levels in wild populations of roe deer

Jean-François Lemaître, Jeffrey Carbillet, Benjamin Rey, Rupert Palme, Hannah Froy, Rachael V. Wilbourn, Sarah L. Underwood, Louise Cheynel, Jean-Michel Gaillard, A.J. Mark Hewison, Hélène Verheyden, François Débias, Jeanne Duhayer, Corinne Régis, Sylvia Pardonnet, Maryline Pellerin, Daniel H. Nussey, Emmanuelle Gilot-Fromont

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

While evidence that telomere length is associated with health and mortality in humans and birds is accumulating, a large body of research is currently seeking to identify factors that modulate telomere dynamics. We tested the hypothesis that high levels of glucocorticoids in individuals under environmental stress should accelerate telomere shortening in two wild populations of roe deer (Capreolus capreolus) living in different ecological contexts. From two consecutive annual sampling sessions, we found that individuals with faster rates of telomere shortening had higher concentrations of fecal glucocorticoid metabolites, suggesting a functional link between glucocorticoid levels and telomere attrition rate. This relationship was consistent for both sexes and populations. This finding paves the way for further studies of the fitness consequences of exposure to environmental stressors in wild vertebrates.

Original language	English
Article number	110836
Number of pages	27
Journal	Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology
Volume	252
Early online date	2 Nov 2020
DOIs	https://doi.org/10.1016/j.cbpa.2020.110836
Publication status	Published - 1 Feb 2021

Keywords / Materials (for Non-textual outputs)

aging
capreolus capreolus
fecal glucocorticoid metabolites
life history
senescence
stress

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10.1016/j.cbpa.2020.110836Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

GilotFromontEtal2021ShortTermTelomereDynamicsAccepted author manuscript, 988 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

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Lemaître, J.-F., Carbillet, J., Rey, B., Palme, R., Froy, H., Wilbourn, R. V., Underwood, S. L., Cheynel, L., Gaillard, J.-M., Hewison, A. J. M., Verheyden, H., Débias, F., Duhayer, J., Régis, C., Pardonnet, S., Pellerin, M., Nussey, D. H., & Gilot-Fromont, E. (2021). Short-term telomere dynamics is associated with glucocorticoid levels in wild populations of roe deer. Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology, 252, Article 110836. https://doi.org/10.1016/j.cbpa.2020.110836

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title = "Short-term telomere dynamics is associated with glucocorticoid levels in wild populations of roe deer",

abstract = "While evidence that telomere length is associated with health and mortality in humans and birds is accumulating, a large body of research is currently seeking to identify factors that modulate telomere dynamics. We tested the hypothesis that high levels of glucocorticoids in individuals under environmental stress should accelerate telomere shortening in two wild populations of roe deer (Capreolus capreolus) living in different ecological contexts. From two consecutive annual sampling sessions, we found that individuals with faster rates of telomere shortening had higher concentrations of fecal glucocorticoid metabolites, suggesting a functional link between glucocorticoid levels and telomere attrition rate. This relationship was consistent for both sexes and populations. This finding paves the way for further studies of the fitness consequences of exposure to environmental stressors in wild vertebrates.",

keywords = "aging, capreolus capreolus, fecal glucocorticoid metabolites, life history, senescence, stress",

author = "Jean-Fran{\c c}ois Lema{\^i}tre and Jeffrey Carbillet and Benjamin Rey and Rupert Palme and Hannah Froy and Wilbourn, {Rachael V.} and Underwood, {Sarah L.} and Louise Cheynel and Jean-Michel Gaillard and Hewison, {A.J. Mark} and H{\'e}l{\`e}ne Verheyden and Fran{\c c}ois D{\'e}bias and Jeanne Duhayer and Corinne R{\'e}gis and Sylvia Pardonnet and Maryline Pellerin and Nussey, {Daniel H.} and Emmanuelle Gilot-Fromont",

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day = "1",

doi = "10.1016/j.cbpa.2020.110836",

language = "English",

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journal = "Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology",

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Lemaître, J-F, Carbillet, J, Rey, B, Palme, R, Froy, H, Wilbourn, RV, Underwood, SL, Cheynel, L, Gaillard, J-M, Hewison, AJM, Verheyden, H, Débias, F, Duhayer, J, Régis, C, Pardonnet, S, Pellerin, M, Nussey, DH & Gilot-Fromont, E 2021, 'Short-term telomere dynamics is associated with glucocorticoid levels in wild populations of roe deer', Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology, vol. 252, 110836. https://doi.org/10.1016/j.cbpa.2020.110836

TY - JOUR

T1 - Short-term telomere dynamics is associated with glucocorticoid levels in wild populations of roe deer

AU - Lemaître, Jean-François

AU - Carbillet, Jeffrey

AU - Rey, Benjamin

AU - Palme, Rupert

AU - Froy, Hannah

AU - Wilbourn, Rachael V.

AU - Underwood, Sarah L.

AU - Cheynel, Louise

AU - Gaillard, Jean-Michel

AU - Hewison, A.J. Mark

AU - Verheyden, Hélène

AU - Débias, François

AU - Duhayer, Jeanne

AU - Régis, Corinne

AU - Pardonnet, Sylvia

AU - Pellerin, Maryline

AU - Nussey, Daniel H.

AU - Gilot-Fromont, Emmanuelle

PY - 2021/2/1

Y1 - 2021/2/1

N2 - While evidence that telomere length is associated with health and mortality in humans and birds is accumulating, a large body of research is currently seeking to identify factors that modulate telomere dynamics. We tested the hypothesis that high levels of glucocorticoids in individuals under environmental stress should accelerate telomere shortening in two wild populations of roe deer (Capreolus capreolus) living in different ecological contexts. From two consecutive annual sampling sessions, we found that individuals with faster rates of telomere shortening had higher concentrations of fecal glucocorticoid metabolites, suggesting a functional link between glucocorticoid levels and telomere attrition rate. This relationship was consistent for both sexes and populations. This finding paves the way for further studies of the fitness consequences of exposure to environmental stressors in wild vertebrates.

AB - While evidence that telomere length is associated with health and mortality in humans and birds is accumulating, a large body of research is currently seeking to identify factors that modulate telomere dynamics. We tested the hypothesis that high levels of glucocorticoids in individuals under environmental stress should accelerate telomere shortening in two wild populations of roe deer (Capreolus capreolus) living in different ecological contexts. From two consecutive annual sampling sessions, we found that individuals with faster rates of telomere shortening had higher concentrations of fecal glucocorticoid metabolites, suggesting a functional link between glucocorticoid levels and telomere attrition rate. This relationship was consistent for both sexes and populations. This finding paves the way for further studies of the fitness consequences of exposure to environmental stressors in wild vertebrates.

KW - aging

KW - capreolus capreolus

KW - fecal glucocorticoid metabolites

KW - life history

KW - senescence

KW - stress

U2 - 10.1016/j.cbpa.2020.110836

DO - 10.1016/j.cbpa.2020.110836

M3 - Article

SN - 1095-6433

VL - 252

JO - Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology

JF - Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology

M1 - 110836

ER -

Short-term telomere dynamics is associated with glucocorticoid levels in wild populations of roe deer

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Keywords / Materials (for Non-textual outputs)

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