Shugoshin promotes sister kinetochore biorientation in Saccharomyces cerevisiae

Brendan M Kiburz, Angelika Amon, Adele L Marston

Research output: Contribution to journalArticlepeer-review

Abstract

Chromosome segregation must be executed accurately during both mitotic and meiotic cell divisions. Sgo1 plays a key role in ensuring faithful chromosome segregation in at least two ways. During meiosis this protein regulates the removal of cohesins, the proteins that hold sister chromatids together, from chromosomes. During mitosis, Sgo1 is required for sensing the absence of tension caused by sister kinetochores not being attached to microtubules emanating from opposite poles. Here we describe a differential requirement for Sgo1 in the segregation of homologous chromosomes and sister chromatids. Sgo1 plays only a minor role in segregating homologous chromosomes at meiosis I. In contrast, Sgo1 is important to bias sister kinetochores toward biorientation. We suggest that Sgo1 acts at sister kinetochores to promote their biorientation.
Original languageEnglish
Pages (from-to)1199-209
Number of pages11
JournalMolecular Biology of the Cell
Volume19
Issue number3
DOIs
Publication statusPublished - 2008

Fingerprint Dive into the research topics of 'Shugoshin promotes sister kinetochore biorientation in Saccharomyces cerevisiae'. Together they form a unique fingerprint.

Cite this