Signal integration between IFNgamma and TLR signalling pathways in macrophages

Kate Schroder, Matthew J Sweet, David A Hume

Research output: Contribution to journalArticlepeer-review

Abstract

Macrophages are major effector cells of the innate immune system, and appropriate regulation of macrophage function requires the integration of multiple signalling inputs derived from the recognition of host factors (e.g. interferon-gamma/IFNgamma) and pathogen products (e.g. toll-like receptor/TLR agonists). The profound effects of IFNgamma pre-treatment ("priming") on TLR-induced macrophage activation have long been recognised, but many of the mechanisms underlying the priming phenotype have only recently been identified. This review summarises the known mechanisms of integration between the IFNgamma and TLR signalling pathways. Synergy occurs at multiple levels, ranging from signal recognition to convergence of signals at the promoters of target genes. In particular, the cross-talk between the IFNgamma, and LPS and CpG DNA signalling pathways is discussed.
Original languageEnglish
Pages (from-to)511-24
Number of pages14
JournalImmunobiology
Volume211
Issue number6-8
DOIs
Publication statusPublished - 2006

Keywords

  • Animals
  • Humans
  • Interferon-gamma
  • Macrophages
  • Signal Transduction
  • Toll-Like Receptors

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