Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells

T Burdon; I Chambers; C Stracey; H Niwa; A Smith

doi:10.1159/000016693

Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells

T Burdon, I Chambers, C Stracey, H Niwa, A Smith

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

An ability to propagate pluripotent embryonic cells in culture is the foundation both for defined germline modification in experimental rodents and for future possibilities for broad-based cellular transplantation therapies in humans. Yet, the molecular basis of the self-renewing pluripotent phenotype remains ill-defined. The relationship between factors that influence embryonic stem cell propagation in vitro and mechanisms of stem cell regulation operative in the embryo is also uncertain. In this article we discuss the role of intracellular signalling pathways in the maintenance of pluripotency and induction of differentiation in embryonic stem cell cultures and the mammalian embryo.

Original language	English
Pages (from-to)	131-43
Number of pages	13
Journal	Cells tissues organs
Volume	165
Issue number	3-4
DOIs	https://doi.org/10.1159/000016693
Publication status	Published - 1999

Keywords / Materials (for Non-textual outputs)

Animals
Cell Differentiation
Cells, Cultured
Fetus
Mice
Signal Transduction
Stem Cells

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10.1159/000016693

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title = "Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells",

abstract = "An ability to propagate pluripotent embryonic cells in culture is the foundation both for defined germline modification in experimental rodents and for future possibilities for broad-based cellular transplantation therapies in humans. Yet, the molecular basis of the self-renewing pluripotent phenotype remains ill-defined. The relationship between factors that influence embryonic stem cell propagation in vitro and mechanisms of stem cell regulation operative in the embryo is also uncertain. In this article we discuss the role of intracellular signalling pathways in the maintenance of pluripotency and induction of differentiation in embryonic stem cell cultures and the mammalian embryo.",

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author = "T Burdon and I Chambers and C Stracey and H Niwa and A Smith",

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T1 - Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells

AU - Burdon, T

AU - Chambers, I

AU - Stracey, C

AU - Niwa, H

AU - Smith, A

PY - 1999

Y1 - 1999

N2 - An ability to propagate pluripotent embryonic cells in culture is the foundation both for defined germline modification in experimental rodents and for future possibilities for broad-based cellular transplantation therapies in humans. Yet, the molecular basis of the self-renewing pluripotent phenotype remains ill-defined. The relationship between factors that influence embryonic stem cell propagation in vitro and mechanisms of stem cell regulation operative in the embryo is also uncertain. In this article we discuss the role of intracellular signalling pathways in the maintenance of pluripotency and induction of differentiation in embryonic stem cell cultures and the mammalian embryo.

AB - An ability to propagate pluripotent embryonic cells in culture is the foundation both for defined germline modification in experimental rodents and for future possibilities for broad-based cellular transplantation therapies in humans. Yet, the molecular basis of the self-renewing pluripotent phenotype remains ill-defined. The relationship between factors that influence embryonic stem cell propagation in vitro and mechanisms of stem cell regulation operative in the embryo is also uncertain. In this article we discuss the role of intracellular signalling pathways in the maintenance of pluripotency and induction of differentiation in embryonic stem cell cultures and the mammalian embryo.

KW - Animals

KW - Cell Differentiation

KW - Cells, Cultured

KW - Fetus

KW - Mice

KW - Signal Transduction

KW - Stem Cells

U2 - 10.1159/000016693

DO - 10.1159/000016693

M3 - Article

C2 - 10592385

SN - 1422-6405

VL - 165

SP - 131

EP - 143

JO - Cells tissues organs

JF - Cells tissues organs

IS - 3-4

ER -

Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells

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Keywords / Materials (for Non-textual outputs)

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