Significance of autoantibodies to purified proteinase 3 in systemic vasculitis

G Gaskin, J J Ryan, A J Rees, C D Pusey, A Neil Turner

Research output: Contribution to journalArticlepeer-review


Proteinase 3 was purified from human neutrophils and used in ELISA to examine sera from 150 patients with systemic vasculitis. It was found to be the major target of autoantibodies in Wegener's granulomatosis, and anti-proteinase 3 antibodies were also found in some patients with microscopic polyarteritis. Anti-proteinase 3 antibodies were associated with a chronic relapsing course.

Original languageEnglish
Pages (from-to)287-9
Number of pages3
JournalAdvances in Experimental Medicine and Biology
Publication statusPublished - 1993


  • Antibodies, Antineutrophil Cytoplasmic
  • Antibody Specificity
  • Autoantibodies
  • Autoantigens
  • Granulomatosis with Polyangiitis
  • Humans
  • Immunoglobulin G
  • Myeloblastin
  • Neutrophils
  • Serine Endopeptidases
  • Vasculitis

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