Abstract / Description of output
Diversity of viral genetic sequences depends on epidemiological mechanisms and dynamics, however the exact mechanisms responsible for patterns observed in phylogenies of HIV remain poorly understood. We observe that virus taken from patients with early/acute HIV infection are more likely to be closely related. By developing a mathematical model of HIV transmission, we show how these and other patterns arise as a simple consequence of intensified transmission during the early/acute stage of HIV infection, however observing these patterns is highly dependent on sampling a significant fraction of prevalent infections.
Original language | English |
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Article number | e1002552 |
Journal | PLoS Computational Biology |
Volume | 8 |
Issue number | 6 |
DOIs | |
Publication status | Published - 28 Jun 2012 |