Simplifying native chemical ligation with an N-acylsulfonamide linker

Fabienne Burlina, Caroline Morris, Raymond Behrendt, Peter White*, John Offer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We report a simplified procedure for the chemical ligation of peptides by using the sulfamylbutyryl linker as a mildly activating group capable of participating in ligation. When the peptidyl N-methylsulfonamide is directly added with excess thiols to ligation reactions, the speed of reaction is comparable to native chemical ligation.

Original languageEnglish
Pages (from-to)2579-2581
Number of pages3
JournalChemical Communications
Issue number20
Publication statusPublished - 8 Feb 2012


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