TY - JOUR
T1 - Simulating human cardiac electrophysiology on clinical time-scales
AU - Niederer, Steven
AU - Mitchell, Lawrence
AU - Smith, Nicolas
AU - Plank, Gernot
PY - 2011
Y1 - 2011
N2 - In this study, the feasibility of conducting in silico experiments in near-realtime with anatomically realistic, biophysically detailed models of human cardiac electrophysiology is demonstrated using a current national high-performance computing facility. The required performance is achieved by integrating and optimizing load balancing and parallel I/O, which lead to strongly scalable simulations up to 16,384 compute cores. This degree of parallelization enables computer simulations of human cardiac electrophysiology at 240 times slower than real time and activation times can be simulated in approximately 1 min. This unprecedented speed suffices requirements for introducing in silico experimentation into a clinical workflow.
AB - In this study, the feasibility of conducting in silico experiments in near-realtime with anatomically realistic, biophysically detailed models of human cardiac electrophysiology is demonstrated using a current national high-performance computing facility. The required performance is achieved by integrating and optimizing load balancing and parallel I/O, which lead to strongly scalable simulations up to 16,384 compute cores. This degree of parallelization enables computer simulations of human cardiac electrophysiology at 240 times slower than real time and activation times can be simulated in approximately 1 min. This unprecedented speed suffices requirements for introducing in silico experimentation into a clinical workflow.
UR - http://www.scopus.com/inward/record.url?scp=84860392008&partnerID=8YFLogxK
U2 - 10.3389/fphys.2011.00014
DO - 10.3389/fphys.2011.00014
M3 - Article
C2 - 21516246
SN - 1664-042X
VL - 2
SP - 14
JO - Frontiers in physiology
JF - Frontiers in physiology
ER -