Simulation of host-microbiome evolution throughout a divergent selection experiment

Cristina Casto-Rebollo*, Ivan Pocrnic, Gregor Gorjanc, Noelia Ibanez-Escriche

*Corresponding author for this work

Research output: Contribution to conferencePaperpeer-review

Abstract / Description of output

The microbiome composition influences the host response to selection and shapes complex phenotypes. It is a multifactorial complex trait in which the microbial inheritance, the host-genome, and the own microbial interactions influence its variability. The expensive sequence-based techniques limit the availability of empirical data. Thus, other approaches are necessary to evaluate strategies for microbiome studies. This study aimed to develop a simulator following a long-term phenotype selection experiment in rabbits, considering both genome and microbiome inheritance. The result showed genetic, microbiome, and phenotypic trends across 13 generations. Differences in the microbiome contribution to the phenotype were shown only in the scenario with a high host genetic effect of the microbiome. This is a preliminary work and further improvements to the simulator will be shared with the research community.
Original languageEnglish
Publication statusPublished - 8 Jul 2022
EventWorld Congress on Genetics Applied Livestock Production
- Rotterdam, Netherlands
Duration: 3 Jul 20228 Jul 2022


ConferenceWorld Congress on Genetics Applied Livestock Production
Internet address


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