Simultaneous G-quadruplex DNA Logic

Antoine Bader, Scott Cockroft

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

A fundamental principle of digital computer operation is Boolean logic, where inputs and outputs are described by binary integer voltages. Similarly, inputs and outputs may be processed on the molecular level as exemplified by synthetic circuits that exploit the programmability of DNA base-pairing. Unlike modern computers, which execute large numbers of logic gates in parallel, most implementations of molecular logic have been limited to single
computing tasks, or sensing applications. Here we report three Gquadruplex-
based logic gates that operate simultaneously in a single reaction vessel. The gates respond to unique Boolean DNA inputs by undergoing topological conversion from duplex to G-quadruplex states that were resolved using a thioflavin T dye and gelelectrophoresis. The modular, addressable and label-free approach could be incorporated into DNA-based sensors, or used for resolving and debugging parallel processes in DNA computing applications.
Original languageEnglish
JournalChemistry - A European Journal
Early online date15 Feb 2018
DOIs
Publication statusE-pub ahead of print - 15 Feb 2018

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