Single nucleotide polymorphisms in major histocompatibility class II haplotypes are associated with potential resistance to inflammatory bowel disease in German shepherd dogs

Atiyeh Peiravan, Karin Allenspach, Alisdair M Boag, Francesca Soutter, Angela Holder, Brian Catchpole, Lorna J Kennedy, Dirk Werling, Fabio Procoli

Research output: Contribution to journalArticlepeer-review

Abstract

German shepherd dogs (GSD) in the UK are at increased risk of developing the Inflammatory Bowel Disaese (IBD). IBD is believed to be a multifactorial immune mediated disease affecting genetically predisposed dogs. The aim of the current study was to investigate whether susceptibility to IBD in GSD is associated with the major histocompatibility complex (MHC) class II locus (Dog Leukocyte Antigen, DLA). Sequence-based genotyping of the three polymorphic DLA genes DLA-DRB1, -DQA1 and -DQB1 was performed in 56 GSDs affected by IBD and in 50 breed-matched controls without any history of gastrointestinal signs. The haplotype DLA-DRB1*015:02-DQA1*006:01-DQB1*023:01 was found to be present only in the control population and was associated with a reduced risk of IBD (P<0.001). In contrast, the haplotype DLA-DRB1*015:01-DQA1*006:01-DQB1*003:01 was associated with IBD (Odds ratio [OR]=1.93, confidence interval [CI]=1.02-3.67, P=0.05). This study has identified an association between DLA-type and canine IBD, supporting the immunogenetic aetiology and immunopathogenesis of this disease.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalVeterinary Immunology and Immunopathology
Volume182
Early online date22 Oct 2016
DOIs
Publication statusE-pub ahead of print - 22 Oct 2016
Externally publishedYes

Keywords

  • Canine
  • GSD
  • Inflammatory bowel disease
  • MHC II
  • DLA II

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