Six-Minute-Walk Test in Chronic Obstructive Pulmonary Disease: Minimal Clinically Important Difference for Death or Hospitalization

Evaluation COPD Longitudinally Ide; Michael I. Polkey; Martijn A. Spruit; Lisa D. Edwards; Michael L. Watkins; Victor Pinto-Plata; Jorgen Vestbo; Peter M. A. Calverley; Ruth Tal-Singer; Alvar Agusti; Per S. Bakke; Harvey O. Coxson; David A. Lomas; William MacNee; Stephen Rennard; Edwin K. Silverman; Bruce E. Miller; Courtney Crim; Julie Yates; Emiel F. M. Wouters; Bartolome Celli

doi:10.1164/rccm.201209-1596OC

Six-Minute-Walk Test in Chronic Obstructive Pulmonary Disease: Minimal Clinically Important Difference for Death or Hospitalization

Evaluation COPD Longitudinally Ide, Michael I. Polkey^*, Martijn A. Spruit, Lisa D. Edwards, Michael L. Watkins, Victor Pinto-Plata, Jorgen Vestbo, Peter M. A. Calverley, Ruth Tal-Singer, Alvar Agusti, Per S. Bakke, Harvey O. Coxson, David A. Lomas, William MacNee, Stephen Rennard, Edwin K. Silverman, Bruce E. Miller, Courtney Crim, Julie Yates, Emiel F. M. WoutersBartolome Celli

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Rationale: Outcomes other than spirometry are required to assess nonbronchodilator therapies for chronic obstructive pulmonary disease. Estimates of the minimal clinically important difference for the 6-minute-walk distance (6MWD) have been derived from narrow cohorts using nonblinded intervention.

Objectives: To determine minimum clinically important difference for change in 6MWD over 1 year as a function of mortality and first hospitalization in an observational cohort of patients with COPD. Methods: Data from the ECLIPSE cohort were used (n = 2,112). Death or first hospitalization were index events; we measured change in 6MWD in the 12-month period before the event and related change in 6MWD to lung function and St. George's Respiratory Questionnaire (health status).

Measurement and Main Results: Of subjects with change in the 6MWD data, 94 died, and 323 were hospitalized. 6MWD fell by 29.7 m (SD, 82.9 m) more among those who died than among survivors (P <0.001). A reduction in distance of more than 30 m conferred a hazard ratio of 1.93(95% confidence interval, 1.29-2.90; P=0.001) for death. No significant difference was observed for first hospitalization. Weak relationships only were observed with change in lung function or health status.

Conclusions: A reduction in the 6MWD of 30 m or more is associated with increased risk of death but not hospitalization due to exacerbation in patients with chronic obstructive pulmonary disease and represents a clinically significant minimally important difference.

Original language	English
Pages (from-to)	382-386
Number of pages	5
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	187
Issue number	4
DOIs	https://doi.org/10.1164/rccm.201209-1596OC
Publication status	Published - 15 Feb 2013

Keywords / Materials (for Non-textual outputs)

hospitalization
VALIDATION
6MW
RANDOMIZED-TRIAL
ECLIPSE COHORT
death
MCID
WALK DISTANCE
MORTALITY
PREVENTION
SEVERE COPD
EXACERBATION
COPD

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10.1164/rccm.201209-1596OC

http://www.atsjournals.org/doi/abs/10.1164/rccm.201209-1596OC#.VCqSdRAkRBk

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J.
MRC
1/09/12 → 31/08/16
Project: Research

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Evaluation COPD Longitudinally Ide, Polkey, M. I., Spruit, M. A., Edwards, L. D., Watkins, M. L., Pinto-Plata, V., Vestbo, J., Calverley, P. M. A., Tal-Singer, R., Agusti, A., Bakke, P. S., Coxson, H. O., Lomas, D. A., MacNee, W., Rennard, S., Silverman, E. K., Miller, B. E., Crim, C., Yates, J., ... Celli, B. (2013). Six-Minute-Walk Test in Chronic Obstructive Pulmonary Disease: Minimal Clinically Important Difference for Death or Hospitalization. American Journal of Respiratory and Critical Care Medicine, 187(4), 382-386. https://doi.org/10.1164/rccm.201209-1596OC

@article{ea3bee12214646eea0e933bf4b76c23b,

title = "Six-Minute-Walk Test in Chronic Obstructive Pulmonary Disease: Minimal Clinically Important Difference for Death or Hospitalization",

abstract = "Rationale: Outcomes other than spirometry are required to assess nonbronchodilator therapies for chronic obstructive pulmonary disease. Estimates of the minimal clinically important difference for the 6-minute-walk distance (6MWD) have been derived from narrow cohorts using nonblinded intervention.Objectives: To determine minimum clinically important difference for change in 6MWD over 1 year as a function of mortality and first hospitalization in an observational cohort of patients with COPD. Methods: Data from the ECLIPSE cohort were used (n = 2,112). Death or first hospitalization were index events; we measured change in 6MWD in the 12-month period before the event and related change in 6MWD to lung function and St. George's Respiratory Questionnaire (health status).Measurement and Main Results: Of subjects with change in the 6MWD data, 94 died, and 323 were hospitalized. 6MWD fell by 29.7 m (SD, 82.9 m) more among those who died than among survivors (P <0.001). A reduction in distance of more than 30 m conferred a hazard ratio of 1.93(95% confidence interval, 1.29-2.90; P=0.001) for death. No significant difference was observed for first hospitalization. Weak relationships only were observed with change in lung function or health status.Conclusions: A reduction in the 6MWD of 30 m or more is associated with increased risk of death but not hospitalization due to exacerbation in patients with chronic obstructive pulmonary disease and represents a clinically significant minimally important difference.",

keywords = "hospitalization, VALIDATION, 6MW, RANDOMIZED-TRIAL, ECLIPSE COHORT, death, MCID, WALK DISTANCE, MORTALITY, PREVENTION, SEVERE COPD, EXACERBATION, COPD",

author = "{Evaluation COPD Longitudinally Ide} and Polkey, {Michael I.} and Spruit, {Martijn A.} and Edwards, {Lisa D.} and Watkins, {Michael L.} and Victor Pinto-Plata and Jorgen Vestbo and Calverley, {Peter M. A.} and Ruth Tal-Singer and Alvar Agusti and Bakke, {Per S.} and Coxson, {Harvey O.} and Lomas, {David A.} and William MacNee and Stephen Rennard and Silverman, {Edwin K.} and Miller, {Bruce E.} and Courtney Crim and Julie Yates and Wouters, {Emiel F. M.} and Bartolome Celli",

year = "2013",

month = feb,

day = "15",

doi = "10.1164/rccm.201209-1596OC",

language = "English",

volume = "187",

pages = "382--386",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1073-449X",

publisher = "American Thoracic Society",

number = "4",

}

Evaluation COPD Longitudinally Ide, Polkey, MI, Spruit, MA, Edwards, LD, Watkins, ML, Pinto-Plata, V, Vestbo, J, Calverley, PMA, Tal-Singer, R, Agusti, A, Bakke, PS, Coxson, HO, Lomas, DA, MacNee, W, Rennard, S, Silverman, EK, Miller, BE, Crim, C, Yates, J, Wouters, EFM & Celli, B 2013, 'Six-Minute-Walk Test in Chronic Obstructive Pulmonary Disease: Minimal Clinically Important Difference for Death or Hospitalization', American Journal of Respiratory and Critical Care Medicine, vol. 187, no. 4, pp. 382-386. https://doi.org/10.1164/rccm.201209-1596OC

Six-Minute-Walk Test in Chronic Obstructive Pulmonary Disease: Minimal Clinically Important Difference for Death or Hospitalization. / Evaluation COPD Longitudinally Ide; Polkey, Michael I.; Spruit, Martijn A. et al.
In: American Journal of Respiratory and Critical Care Medicine, Vol. 187, No. 4, 15.02.2013, p. 382-386.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Six-Minute-Walk Test in Chronic Obstructive Pulmonary Disease

T2 - Minimal Clinically Important Difference for Death or Hospitalization

AU - Evaluation COPD Longitudinally Ide

AU - Polkey, Michael I.

AU - Spruit, Martijn A.

AU - Edwards, Lisa D.

AU - Watkins, Michael L.

AU - Pinto-Plata, Victor

AU - Vestbo, Jorgen

AU - Calverley, Peter M. A.

AU - Tal-Singer, Ruth

AU - Agusti, Alvar

AU - Bakke, Per S.

AU - Coxson, Harvey O.

AU - Lomas, David A.

AU - MacNee, William

AU - Rennard, Stephen

AU - Silverman, Edwin K.

AU - Miller, Bruce E.

AU - Crim, Courtney

AU - Yates, Julie

AU - Wouters, Emiel F. M.

AU - Celli, Bartolome

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Rationale: Outcomes other than spirometry are required to assess nonbronchodilator therapies for chronic obstructive pulmonary disease. Estimates of the minimal clinically important difference for the 6-minute-walk distance (6MWD) have been derived from narrow cohorts using nonblinded intervention.Objectives: To determine minimum clinically important difference for change in 6MWD over 1 year as a function of mortality and first hospitalization in an observational cohort of patients with COPD. Methods: Data from the ECLIPSE cohort were used (n = 2,112). Death or first hospitalization were index events; we measured change in 6MWD in the 12-month period before the event and related change in 6MWD to lung function and St. George's Respiratory Questionnaire (health status).Measurement and Main Results: Of subjects with change in the 6MWD data, 94 died, and 323 were hospitalized. 6MWD fell by 29.7 m (SD, 82.9 m) more among those who died than among survivors (P <0.001). A reduction in distance of more than 30 m conferred a hazard ratio of 1.93(95% confidence interval, 1.29-2.90; P=0.001) for death. No significant difference was observed for first hospitalization. Weak relationships only were observed with change in lung function or health status.Conclusions: A reduction in the 6MWD of 30 m or more is associated with increased risk of death but not hospitalization due to exacerbation in patients with chronic obstructive pulmonary disease and represents a clinically significant minimally important difference.

AB - Rationale: Outcomes other than spirometry are required to assess nonbronchodilator therapies for chronic obstructive pulmonary disease. Estimates of the minimal clinically important difference for the 6-minute-walk distance (6MWD) have been derived from narrow cohorts using nonblinded intervention.Objectives: To determine minimum clinically important difference for change in 6MWD over 1 year as a function of mortality and first hospitalization in an observational cohort of patients with COPD. Methods: Data from the ECLIPSE cohort were used (n = 2,112). Death or first hospitalization were index events; we measured change in 6MWD in the 12-month period before the event and related change in 6MWD to lung function and St. George's Respiratory Questionnaire (health status).Measurement and Main Results: Of subjects with change in the 6MWD data, 94 died, and 323 were hospitalized. 6MWD fell by 29.7 m (SD, 82.9 m) more among those who died than among survivors (P <0.001). A reduction in distance of more than 30 m conferred a hazard ratio of 1.93(95% confidence interval, 1.29-2.90; P=0.001) for death. No significant difference was observed for first hospitalization. Weak relationships only were observed with change in lung function or health status.Conclusions: A reduction in the 6MWD of 30 m or more is associated with increased risk of death but not hospitalization due to exacerbation in patients with chronic obstructive pulmonary disease and represents a clinically significant minimally important difference.

KW - hospitalization

KW - VALIDATION

KW - 6MW

KW - RANDOMIZED-TRIAL

KW - ECLIPSE COHORT

KW - death

KW - MCID

KW - WALK DISTANCE

KW - MORTALITY

KW - PREVENTION

KW - SEVERE COPD

KW - EXACERBATION

KW - COPD

U2 - 10.1164/rccm.201209-1596OC

DO - 10.1164/rccm.201209-1596OC

M3 - Article

SN - 1073-449X

VL - 187

SP - 382

EP - 386

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 4

ER -

Six-Minute-Walk Test in Chronic Obstructive Pulmonary Disease: Minimal Clinically Important Difference for Death or Hospitalization

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

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PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

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