Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

UK BiLEVE, María Soler Artigas, Louise V Wain, Suzanne Miller, Abdul Kader Kheirallah, Jennifer E Huffman, Ioanna Ntalla, Nick Shrine, Ma'en Obeidat, Holly Trochet, Wendy L McArdle, Alexessander Couto Alves, Jennie Hui, Jing Hua Zhao, Peter K Joshi, Alexander Teumer, Eva Albrecht, Medea Imboden, Rajesh Rawal, Lorna M LopezJonathan Marten, Stefan Enroth, Ida Surakka, Ozren Polasek, Leo-Pekka Lyytikäinen, Raquel Granell, Pirro G Hysi, Claudia Flexeder, Anubha Mahajan, John Beilby, Yohan Bossé, Corry-Anke Brandsma, Harry Campbell, Christian Gieger, Sven Gläser, Juan R González, Harald Grallert, Chris J Hammond, Sarah E Harris, Anna-Liisa Hartikainen, John Henderson, Pau Navarro, John M Starr, Sarah H Wild, Alan F Wright, Veronique Vitart, Igor Rudan, Ian J Deary, James F Wilson, Andrew P Morris, Caroline Hayward

Research output: Contribution to journalArticlepeer-review

Abstract

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

Original languageEnglish
Pages (from-to)8658
JournalNature Communications
Volume6
DOIs
Publication statusPublished - 4 Dec 2015

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