Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

UK BiLEVE; María Soler Artigas; Louise V Wain; Suzanne Miller; Abdul Kader Kheirallah; Jennifer E Huffman; Ioanna Ntalla; Nick Shrine; Ma'en Obeidat; Holly Trochet; Wendy L McArdle; Alexessander Couto Alves; Jennie Hui; Jing Hua Zhao; Peter K Joshi; Alexander Teumer; Eva Albrecht; Medea Imboden; Rajesh Rawal; Lorna M Lopez; Jonathan Marten; Stefan Enroth; Ida Surakka; Ozren Polasek; Leo-Pekka Lyytikäinen; Raquel Granell; Pirro G Hysi; Claudia Flexeder; Anubha Mahajan; John Beilby; Yohan Bossé; Corry-Anke Brandsma; Harry Campbell; Christian Gieger; Sven Gläser; Juan R González; Harald Grallert; Chris J Hammond; Sarah E Harris; Anna-Liisa Hartikainen; John Henderson; Pau Navarro; John M Starr; Sarah H Wild; Alan F Wright; Veronique Vitart; Igor Rudan; Ian J Deary; James F Wilson; Andrew P Morris; Caroline Hayward

doi:10.1038/ncomms9658

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

UK BiLEVE, María Soler Artigas, Louise V Wain, Suzanne Miller, Abdul Kader Kheirallah, Jennifer E Huffman, Ioanna Ntalla, Nick Shrine, Ma'en Obeidat, Holly Trochet, Wendy L McArdle, Alexessander Couto Alves, Jennie Hui, Jing Hua Zhao, Peter K Joshi, Alexander Teumer, Eva Albrecht, Medea Imboden, Rajesh Rawal, Lorna M LopezJonathan Marten, Stefan Enroth, Ida Surakka, Ozren Polasek, Leo-Pekka Lyytikäinen, Raquel Granell, Pirro G Hysi, Claudia Flexeder, Anubha Mahajan, John Beilby, Yohan Bossé, Corry-Anke Brandsma, Harry Campbell, Christian Gieger, Sven Gläser, Juan R González, Harald Grallert, Chris J Hammond, Sarah E Harris, Anna-Liisa Hartikainen, John Henderson, Pau Navarro, John M Starr, Sarah H Wild, Alan F Wright, Veronique Vitart, Igor Rudan, Ian J Deary, James F Wilson, Andrew P Morris, Caroline Hayward

Research output: Contribution to journal › Article › peer-review

Abstract

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

Original language	English
Pages (from-to)	8658
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms9658
Publication status	Published - 4 Dec 2015

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10.1038/ncomms9658

Campbell H et al Sixteen new lung functions
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RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
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UK BiLEVE, Artigas, M. S., Wain, L. V., Miller, S., Kheirallah, A. K., Huffman, J. E., Ntalla, I., Shrine, N., Obeidat, M., Trochet, H., McArdle, W. L., Alves, A. C., Hui, J., Zhao, J. H., Joshi, P. K., Teumer, A., Albrecht, E., Imboden, M., Rawal, R., ... Hayward, C. (2015). Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6, 8658. https://doi.org/10.1038/ncomms9658

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title = "Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation",

abstract = "Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.",

author = "{UK BiLEVE} and Artigas, {Mar{\'i}a Soler} and Wain, {Louise V} and Suzanne Miller and Kheirallah, {Abdul Kader} and Huffman, {Jennifer E} and Ioanna Ntalla and Nick Shrine and Ma'en Obeidat and Holly Trochet and McArdle, {Wendy L} and Alves, {Alexessander Couto} and Jennie Hui and Zhao, {Jing Hua} and Joshi, {Peter K} and Alexander Teumer and Eva Albrecht and Medea Imboden and Rajesh Rawal and Lopez, {Lorna M} and Jonathan Marten and Stefan Enroth and Ida Surakka and Ozren Polasek and Leo-Pekka Lyytik{\"a}inen and Raquel Granell and Hysi, {Pirro G} and Claudia Flexeder and Anubha Mahajan and John Beilby and Yohan Boss{\'e} and Corry-Anke Brandsma and Harry Campbell and Christian Gieger and Sven Gl{\"a}ser and Gonz{\'a}lez, {Juan R} and Harald Grallert and Hammond, {Chris J} and Harris, {Sarah E} and Anna-Liisa Hartikainen and John Henderson and Pau Navarro and Starr, {John M} and Wild, {Sarah H} and Wright, {Alan F} and Veronique Vitart and Igor Rudan and Deary, {Ian J} and Wilson, {James F} and Morris, {Andrew P} and Caroline Hayward",

year = "2015",

month = dec,

day = "4",

doi = "10.1038/ncomms9658",

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volume = "6",

pages = "8658",

journal = "Nature Communications",

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UK BiLEVE, Artigas, MS, Wain, LV, Miller, S, Kheirallah, AK, Huffman, JE, Ntalla, I, Shrine, N, Obeidat, M, Trochet, H, McArdle, WL, Alves, AC, Hui, J, Zhao, JH, Joshi, PK, Teumer, A, Albrecht, E, Imboden, M, Rawal, R, Lopez, LM, Marten, J, Enroth, S, Surakka, I, Polasek, O, Lyytikäinen, L-P, Granell, R, Hysi, PG, Flexeder, C, Mahajan, A, Beilby, J, Bossé, Y, Brandsma, C-A, Campbell, H, Gieger, C, Gläser, S, González, JR, Grallert, H, Hammond, CJ, Harris, SE, Hartikainen, A-L, Henderson, J, Navarro, P, Starr, JM, Wild, SH, Wright, AF, Vitart, V , Rudan, I , Deary, IJ , Wilson, JF , Morris, AP & Hayward, C 2015, 'Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation', Nature Communications, vol. 6, pp. 8658. https://doi.org/10.1038/ncomms9658

TY - JOUR

T1 - Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

AU - UK BiLEVE

AU - Artigas, María Soler

AU - Wain, Louise V

AU - Miller, Suzanne

AU - Kheirallah, Abdul Kader

AU - Huffman, Jennifer E

AU - Ntalla, Ioanna

AU - Shrine, Nick

AU - Obeidat, Ma'en

AU - Trochet, Holly

AU - McArdle, Wendy L

AU - Alves, Alexessander Couto

AU - Hui, Jennie

AU - Zhao, Jing Hua

AU - Joshi, Peter K

AU - Teumer, Alexander

AU - Albrecht, Eva

AU - Imboden, Medea

AU - Rawal, Rajesh

AU - Lopez, Lorna M

AU - Marten, Jonathan

AU - Enroth, Stefan

AU - Surakka, Ida

AU - Polasek, Ozren

AU - Lyytikäinen, Leo-Pekka

AU - Granell, Raquel

AU - Hysi, Pirro G

AU - Flexeder, Claudia

AU - Mahajan, Anubha

AU - Beilby, John

AU - Bossé, Yohan

AU - Brandsma, Corry-Anke

AU - Campbell, Harry

AU - Gieger, Christian

AU - Gläser, Sven

AU - González, Juan R

AU - Grallert, Harald

AU - Hammond, Chris J

AU - Harris, Sarah E

AU - Hartikainen, Anna-Liisa

AU - Henderson, John

AU - Navarro, Pau

AU - Starr, John M

AU - Wild, Sarah H

AU - Wright, Alan F

AU - Vitart, Veronique

AU - Rudan, Igor

AU - Deary, Ian J

AU - Wilson, James F

AU - Morris, Andrew P

AU - Hayward, Caroline

PY - 2015/12/4

Y1 - 2015/12/4

N2 - Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

AB - Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

U2 - 10.1038/ncomms9658

DO - 10.1038/ncomms9658

M3 - Article

C2 - 26635082

VL - 6

SP - 8658

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Abstract

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RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

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