Skeletal and Cardiac Muscle Pericytes: Functions and Therapeutic Potential

Iain R Murray, James Baily, William C W Chen, Ayelet Dar, Zaniah N Gonzalez, Andrew R Jensen, Frank A Petrigliano, Arjun Deb, Neil C Henderson

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Pericytes are periendothelial mesenchymal cells residing within the microvasculature. Skeletal muscle and cardiac pericytes are now recognised to fulfil an increasing number of functions in normal tissue homeostasis including contributing to microvascular function by maintaining vessel stability and regulating capillary flow. In the setting of muscle injury, pericytes contribute to a regenerative microenvironment through release of trophic factors and by modulating local immune responses. In skeletal muscle, pericytes also directly enhance tissue healing by differentiating into myofibers. Conversely, pericytes have also been implicated in the development of disease states including fibrosis, heterotopic ossication and calcification, atherosclerosis and tumour angiogenesis. Despite increased recognition of pericyte heterogeneity, it is not yet clear whether specific subsets of pericytes are responsible for individual functions in skeletal and cardiac muscle homeostasis and disease.

Original languageEnglish
JournalPharmacology and Therapeutics
Volume171
Early online date2 Sep 2016
DOIs
Publication statusPublished - Mar 2017

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