TY - JOUR
T1 - Skeletal and Cardiac Muscle Pericytes
T2 - Functions and Therapeutic Potential
AU - Murray, Iain R
AU - Baily, James
AU - Chen, William C W
AU - Dar, Ayelet
AU - Gonzalez, Zaniah N
AU - Jensen, Andrew R
AU - Petrigliano, Frank A
AU - Deb, Arjun
AU - Henderson, Neil C
N1 - Copyright © 2016. Published by Elsevier Inc.
PY - 2017/3
Y1 - 2017/3
N2 - Pericytes are periendothelial mesenchymal cells residing within the microvasculature. Skeletal muscle and cardiac pericytes are now recognised to fulfil an increasing number of functions in normal tissue homeostasis including contributing to microvascular function by maintaining vessel stability and regulating capillary flow. In the setting of muscle injury, pericytes contribute to a regenerative microenvironment through release of trophic factors and by modulating local immune responses. In skeletal muscle, pericytes also directly enhance tissue healing by differentiating into myofibers. Conversely, pericytes have also been implicated in the development of disease states including fibrosis, heterotopic ossication and calcification, atherosclerosis and tumour angiogenesis. Despite increased recognition of pericyte heterogeneity, it is not yet clear whether specific subsets of pericytes are responsible for individual functions in skeletal and cardiac muscle homeostasis and disease.
AB - Pericytes are periendothelial mesenchymal cells residing within the microvasculature. Skeletal muscle and cardiac pericytes are now recognised to fulfil an increasing number of functions in normal tissue homeostasis including contributing to microvascular function by maintaining vessel stability and regulating capillary flow. In the setting of muscle injury, pericytes contribute to a regenerative microenvironment through release of trophic factors and by modulating local immune responses. In skeletal muscle, pericytes also directly enhance tissue healing by differentiating into myofibers. Conversely, pericytes have also been implicated in the development of disease states including fibrosis, heterotopic ossication and calcification, atherosclerosis and tumour angiogenesis. Despite increased recognition of pericyte heterogeneity, it is not yet clear whether specific subsets of pericytes are responsible for individual functions in skeletal and cardiac muscle homeostasis and disease.
U2 - 10.1016/j.pharmthera.2016.09.005
DO - 10.1016/j.pharmthera.2016.09.005
M3 - Literature review
C2 - 27595928
SN - 0163-7258
VL - 171
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
ER -