TY - JOUR
T1 - Small molecule screening in zebrafish
T2 - an in vivo approach to identifying new chemical tools and drug leads
AU - Taylor, Kerrie L
AU - Grant, Nicola J
AU - Temperley, Nicholas D
AU - Patton, E Elizabeth
PY - 2010/6/12
Y1 - 2010/6/12
N2 - In the past two decades, zebrafish genetic screens have identified a wealth of mutations that have been essential to the understanding of development and disease biology. More recently, chemical screens in zebrafish have identified small molecules that can modulate specific developmental and behavioural processes. Zebrafish are a unique vertebrate system in which to study chemical genetic systems, identify drug leads, and explore new applications for known drugs. Here, we discuss some of the advantages of using zebrafish in chemical biology, and describe some important and creative examples of small molecule screening, drug discovery and target identification.
AB - In the past two decades, zebrafish genetic screens have identified a wealth of mutations that have been essential to the understanding of development and disease biology. More recently, chemical screens in zebrafish have identified small molecules that can modulate specific developmental and behavioural processes. Zebrafish are a unique vertebrate system in which to study chemical genetic systems, identify drug leads, and explore new applications for known drugs. Here, we discuss some of the advantages of using zebrafish in chemical biology, and describe some important and creative examples of small molecule screening, drug discovery and target identification.
U2 - 10.1186/1478-811X-8-11
DO - 10.1186/1478-811X-8-11
M3 - Article
C2 - 20540792
SN - 1478-811X
VL - 8
SP - -
JO - Cell communication and signaling
JF - Cell communication and signaling
M1 - 11
ER -