Small Ruminant Lentiviruses and Human Immunodeficiency Virus: Cousins that Take a Long View

Barbara A. Blacklaws, Gordon D. Harkiss

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Small ruminant lentiviruses (SRLV) and human immunodeficiency viruses (HIV) are related retroviruses that cause multisystem disease usually over a long period of time. The viruses show similarities and differences in biological and pathogenic features. The basic retroviral genomic organization is complicated by the presence of a variable number of accessory genes in both viruses, though the structure is more complex in HIV. Both are mucosal pathogens, and infect cells of the monocyte-macrophage lineage. The main difference in cell tropism is that, unlike HIV, SRLV do not infect lymphocytes. A major feature of both pathogens is restricted replication and virus latency, which are partly responsible for the establishment of chronic infection usually lasting for life. The pathologies observed are similar in the early stages of both infections, and possibly following highly active anti-retroviral therapy (HAART). While the pathogenesis of HIV-induced disease during symptomatic stages is mainly due to secondary infections and neoplastic conditions, the early and post-HAART stages are associated with chronic inflammatory changes that resemble those found in SRLV diseases which are thought to be mediated by anti-virus immune responses.

Original languageEnglish
Pages (from-to)26-52
Number of pages27
JournalCurrent HIV Research: HIV and Viral Immune Diseases
Issue number1
Publication statusPublished - Jan 2010


Dive into the research topics of 'Small Ruminant Lentiviruses and Human Immunodeficiency Virus: Cousins that Take a Long View'. Together they form a unique fingerprint.

Cite this