Small variable segments constitute a major type of diversity of bacterial genomes at the species level

Fabrice Touzain; Erick Denamur; Claudine Médigue; Valérie Barbe; Meriem El Karoui; Marie-Agnès Petit

doi:10.1186/gb-2010-11-4-r45

Small variable segments constitute a major type of diversity of bacterial genomes at the species level

Fabrice Touzain, Erick Denamur, Claudine Médigue, Valérie Barbe, Meriem El Karoui, Marie-Agnès Petit

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Analysis of large scale diversity in bacterial genomes has mainly focused on elements such as pathogenicity islands, or more generally, genomic islands. These comprise numerous genes and confer important phenotypes, which are present or absent depending on strains. We report that despite this widely accepted notion, most diversity at the species level is composed of much smaller DNA segments, 20 to 500 bp in size, which we call microdiversity.

Original language	English
Article number	R45
Journal	Genome Biology
Volume	11
Issue number	4
DOIs	https://doi.org/10.1186/gb-2010-11-4-r45
Publication status	Published - 2010

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title = "Small variable segments constitute a major type of diversity of bacterial genomes at the species level",

abstract = "Analysis of large scale diversity in bacterial genomes has mainly focused on elements such as pathogenicity islands, or more generally, genomic islands. These comprise numerous genes and confer important phenotypes, which are present or absent depending on strains. We report that despite this widely accepted notion, most diversity at the species level is composed of much smaller DNA segments, 20 to 500 bp in size, which we call microdiversity.",

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AU - Denamur, Erick

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AU - Barbe, Valérie

AU - El Karoui, Meriem

AU - Petit, Marie-Agnès

PY - 2010

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AB - Analysis of large scale diversity in bacterial genomes has mainly focused on elements such as pathogenicity islands, or more generally, genomic islands. These comprise numerous genes and confer important phenotypes, which are present or absent depending on strains. We report that despite this widely accepted notion, most diversity at the species level is composed of much smaller DNA segments, 20 to 500 bp in size, which we call microdiversity.

U2 - 10.1186/gb-2010-11-4-r45

DO - 10.1186/gb-2010-11-4-r45

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JO - Genome Biology

JF - Genome Biology

SN - 1465-6906

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Small variable segments constitute a major type of diversity of bacterial genomes at the species level

Abstract

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