Small vessel disease and dietary salt intake: cross sectional study and systematic review

Stephen Makin; Ghaida F  Mubki; Fergus Doubal; Kirsten Shuler; Julie Staals; Martin Dennis; Joanna Wardlaw

doi:10.1016/j.jstrokecerebrovasdis.2017.08.004

Small vessel disease and dietary salt intake: cross sectional study and systematic review

Stephen Makin, Ghaida F Mubki, Fergus Doubal, Kirsten Shuler, Julie Staals, Martin Dennis, Joanna Wardlaw

Research output: Contribution to journal › Article › peer-review

Abstract

Higher dietary salt intake increases the risk of stroke and may increase white matter hyperintensity volume. We hypothesised that a higher salt intake longterm may be associated with other features of small vessel disease.
We recruited 250 patients, 112 lacunar, and 138 cortical stroke, median age 67.5, performed brain MRI, obtained a basic dietary salt history and measured urinary sodium/creatinine ratio. After adjustment for risk factors, including age and hypertension, patients who had not reduced their salt intake longterm were more likely to have lacunar stroke (OR 1.90,95% CI 1.10-3.29), lacune(s) (OR 2.06 95%CI 1.09-3.99), microbleed(s) (OR 3.4 95%CI 1.54,8.21), severe white matter hyperintensities (OR 2.45 95%CI 1.34-4.57) and worse small vessel disease score (OR 2.17 95%CI 1.22-3.9). There was limited association between small vessel disease and current salt intake, or urinary sodium/creatinine ratio. Our systematic review found no previously published studies of dietary salt and small vessel disease.
These results should be replicated in larger, long term studies.

Original language	English
Journal	Journal of Stroke & Cerebrovascular Diseases
Early online date	8 Sept 2017
DOIs	https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.08.004
Publication status	E-pub ahead of print - 8 Sept 2017

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10.1016/j.jstrokecerebrovasdis.2017.08.004

Small Vessel Disease and Dietary Salt Intake: Cross-Sectional Study and Systematic Review
© 2017 The Authors. Published by Elsevier Inc. on behalf of National Stroke Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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http://www.sciencedirect.com/science/article/pii/S1052305717304147

Understanding the Role of the Perivascular Space in Cerebral Small Vessel Disease
Wardlaw, J. (Principal Investigator)
1/01/17 → 31/12/23
Project: Research
SVDs-at-target: Small vessel diseases in a mechanistic perspective: Targets for Intervention Affected pathways and mechanistic exploitation for prevention of stroke and dementia
Wardlaw, J. (Principal Investigator)
EU government bodies
1/01/16 → 31/12/21
Project: Research
Row Fogo Charitable Trust Funds
Wardlaw, J. (Principal Investigator)
UK-based charities
1/10/15 → 30/09/18
Project: Research

Cite this

@article{5593beefc03e46b9b85d069a5584bd8f,

title = "Small vessel disease and dietary salt intake: cross sectional study and systematic review",

abstract = "Higher dietary salt intake increases the risk of stroke and may increase white matter hyperintensity volume. We hypothesised that a higher salt intake longterm may be associated with other features of small vessel disease.We recruited 250 patients, 112 lacunar, and 138 cortical stroke, median age 67.5, performed brain MRI, obtained a basic dietary salt history and measured urinary sodium/creatinine ratio. After adjustment for risk factors, including age and hypertension, patients who had not reduced their salt intake longterm were more likely to have lacunar stroke (OR 1.90,95% CI 1.10-3.29), lacune(s) (OR 2.06 95%CI 1.09-3.99), microbleed(s) (OR 3.4 95%CI 1.54,8.21), severe white matter hyperintensities (OR 2.45 95%CI 1.34-4.57) and worse small vessel disease score (OR 2.17 95%CI 1.22-3.9). There was limited association between small vessel disease and current salt intake, or urinary sodium/creatinine ratio. Our systematic review found no previously published studies of dietary salt and small vessel disease.These results should be replicated in larger, long term studies.",

author = "Stephen Makin and Mubki, {Ghaida F} and Fergus Doubal and Kirsten Shuler and Julie Staals and Martin Dennis and Joanna Wardlaw",

year = "2017",

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doi = "10.1016/j.jstrokecerebrovasdis.2017.08.004",

language = "English",

journal = "Journal of Stroke & Cerebrovascular Diseases",

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T1 - Small vessel disease and dietary salt intake: cross sectional study and systematic review

AU - Makin, Stephen

AU - Mubki, Ghaida F

AU - Doubal, Fergus

AU - Shuler, Kirsten

AU - Staals, Julie

AU - Dennis, Martin

AU - Wardlaw, Joanna

PY - 2017/9/8

Y1 - 2017/9/8

N2 - Higher dietary salt intake increases the risk of stroke and may increase white matter hyperintensity volume. We hypothesised that a higher salt intake longterm may be associated with other features of small vessel disease.We recruited 250 patients, 112 lacunar, and 138 cortical stroke, median age 67.5, performed brain MRI, obtained a basic dietary salt history and measured urinary sodium/creatinine ratio. After adjustment for risk factors, including age and hypertension, patients who had not reduced their salt intake longterm were more likely to have lacunar stroke (OR 1.90,95% CI 1.10-3.29), lacune(s) (OR 2.06 95%CI 1.09-3.99), microbleed(s) (OR 3.4 95%CI 1.54,8.21), severe white matter hyperintensities (OR 2.45 95%CI 1.34-4.57) and worse small vessel disease score (OR 2.17 95%CI 1.22-3.9). There was limited association between small vessel disease and current salt intake, or urinary sodium/creatinine ratio. Our systematic review found no previously published studies of dietary salt and small vessel disease.These results should be replicated in larger, long term studies.

AB - Higher dietary salt intake increases the risk of stroke and may increase white matter hyperintensity volume. We hypothesised that a higher salt intake longterm may be associated with other features of small vessel disease.We recruited 250 patients, 112 lacunar, and 138 cortical stroke, median age 67.5, performed brain MRI, obtained a basic dietary salt history and measured urinary sodium/creatinine ratio. After adjustment for risk factors, including age and hypertension, patients who had not reduced their salt intake longterm were more likely to have lacunar stroke (OR 1.90,95% CI 1.10-3.29), lacune(s) (OR 2.06 95%CI 1.09-3.99), microbleed(s) (OR 3.4 95%CI 1.54,8.21), severe white matter hyperintensities (OR 2.45 95%CI 1.34-4.57) and worse small vessel disease score (OR 2.17 95%CI 1.22-3.9). There was limited association between small vessel disease and current salt intake, or urinary sodium/creatinine ratio. Our systematic review found no previously published studies of dietary salt and small vessel disease.These results should be replicated in larger, long term studies.

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DO - 10.1016/j.jstrokecerebrovasdis.2017.08.004

M3 - Article

SN - 1532-8511

JO - Journal of Stroke & Cerebrovascular Diseases

JF - Journal of Stroke & Cerebrovascular Diseases

ER -

Small vessel disease and dietary salt intake: cross sectional study and systematic review

Abstract

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Projects

Understanding the Role of the Perivascular Space in Cerebral Small Vessel Disease

SVDs-at-target: Small vessel diseases in a mechanistic perspective: Targets for Intervention Affected pathways and mechanistic exploitation for prevention of stroke and dementia

Row Fogo Charitable Trust Funds

Cite this