SMART: a web-based tool for the study of genetically mobile domains

J Schultz, R R Copley, T Doerks, C P Ponting, P Bork

Research output: Contribution to journalArticlepeer-review

Abstract

SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.embl-heidelberg.de ). More than 400 domain families found in signalling, extra-cellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.

Original languageEnglish
Pages (from-to)231-4
Number of pages4
JournalNucleic Acids Research
Volume28
Issue number1
Publication statusPublished - 1 Jan 2000

Keywords

  • Database Management Systems
  • Information Storage and Retrieval
  • Internet
  • Proteins
  • Sequence Alignment

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