Social networking between cells of the foetal skeleton: the importance of thyroid hormones

Colin Farquharson*

*Corresponding author for this work

Research output: Contribution to journalEditorial

Abstract

In this issue of Journal of Endocrinology, Lanham et al. investigated the effects of hypothyroidism on the developing skeleton of the ovine foetus in utero. Their analyses indicated that, following thyroidectomy, bone growth, structure and mechanical properties were all altered at late gestation or at term. Adrenalectomy, whilst preventing the prepartum rise in triiodothyronine, did not modify skeletal development. The hypothyroid-mediated skeletal defects of the developing foetus described in this study may have clinical implications for bone health in later life. Journal of Endocrinology (2011) 210, 135-136

Original languageEnglish
Pages (from-to)135-136
Number of pages2
JournalJournal of Endocrinology
Volume210
Issue number2
DOIs
Publication statusPublished - Aug 2011

Keywords

  • Thyroid bone hypothyroidism growth skeleton

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