Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes

Alexander H Tuttle, Shannon Tansley, Kimberly Dossett, Sarasa Tohyama, Arkady Khoutorsky, Sioui Maldonado-Bouchard, Liane Stein, Lindsey Gerstein, Hayley Crawhall-Duk, Rebecca Pearl, Melissa Sukosd, Philip Leger, Oliver M Hardt, David Yachnin, Jean-Sebastien Austin, Claire M Chan, Tine Pooters, Isabelle Groves, Loren J Martin, Nahum SonenbergChristos G Gkogkas, Jeffrey S Mogil

Research output: Contribution to journalArticlepeer-review

Abstract

Existing assays of social interaction are suboptimal, and none measures propinquity, the tendency of rodents to maintain close physical proximity. These assays are ubiquitously performed using inbred mouse strains and mutations placed on inbred genetic backgrounds. We developed the automatable tube cooccupancy test (TCOT) based on propinquity, the tendency of freely mobile rodents to maintain close physical proximity, and assessed TCOT behavior on a variety of genotypes and social and environmental conditions. In outbred mice and rats, familiarity determined willingness to cooccupy the tube, with siblings and/or cagemates of both sexes exhibiting higher cooccupancy behavior than strangers. Subsequent testing using multiple genotypes revealed that inbred strain siblings do not cooccupy at higher rates than strangers, in marked contrast to both outbred and rederived wild mice. Mutant mouse strains with "autistic-like" phenotypes (Fmr1(-/y) and Eif4e Ser209Ala) displayed significantly decreased cooccupancy.

Original languageEnglish
Pages (from-to)5515-5520
Number of pages6
JournalProceedings of the National Academy of Sciences
Volume114
Issue number21
DOIs
Publication statusPublished - 23 May 2017

Keywords

  • Journal Article

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