Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons

Yan Tang, Diego Benusiglio, Arthur Lefevre, Louis Hilfiger, Ferdinand Althammer, Anna Bludau, Daisuke Hagiwara, Angel Baudon, Pascal Darbon, Jonas Schimmer, Matthew K. Kirchner, Ranjan K. Roy, Shiyi Wang, Marina Eliava, Shlomo Wagner, Martina Oberhuber, Karl K. Conzelmann, Martin Schwarz, Javier E. Stern, Gareth LengInga D. Neumann, Alexandre Charlet, Valery Grinevich

Research output: Contribution to journalArticlepeer-review

Abstract

Oxytocin (OT) is a great facilitator of social life but, although its effects on socially relevant brain regions have been extensively studied, OT neuron activity during actual social interactions remains unexplored. Most OT neurons are magnocellular neurons, which simultaneously project to the pituitary and forebrain regions involved in social behaviors. In the present study, we show that a much smaller population of OT neurons, parvocellular neurons that do not project to the pituitary but synapse onto magnocellular neurons, is preferentially activated by somatosensory stimuli. This activation is transmitted to the larger population of magnocellular neurons, which consequently show coordinated increases in their activity during social interactions between virgin female rats. Selectively activating these parvocellular neurons promotes social motivation, whereas inhibiting them reduces social interactions. Thus, parvocellular OT neurons receive particular inputs to control social behavior by coordinating the responses of the much larger population of magnocellular OT neurons.
Original languageEnglish
Pages (from-to)1125-1137
Number of pages13
JournalNature Neuroscience
Volume23
Issue number9
Early online date27 Jul 2020
DOIs
Publication statusPublished - 30 Sep 2020

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