Solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor

Marc Vendrell; Gaddamanugu Gopi Krishna; Krishna Kanta Ghosh; Duanting Zhai; Jun-Seok Lee; Qing Zhu; Yin Hoe Yau; Susana Geifman Shochat; Hyori Kim; Junho Chung; Young-Tae Chang

doi:10.1039/c1cc11774b

Solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor

Marc Vendrell
, Gaddamanugu Gopi Krishna
, Krishna Kanta Ghosh
, Duanting Zhai
, Jun-Seok Lee
, Qing Zhu
, Yin Hoe Yau
, Susana Geifman Shochat
, Hyori Kim
, Junho Chung
, Young-Tae Chang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The diversification of the BODIPY scaffold has been hindered by its controversial adaptability to solid-phase chemistry. Herein we report the first solid-phase synthesis of a BODIPY library in high purities. We screened the library against a set of proteins, identified an immunoglobulin fluorescent sensor (Ig Orange) and confirmed its binding by SPR experiments.

Original language	English
Pages (from-to)	8424-8426
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	29
DOIs	https://doi.org/10.1039/c1cc11774b
Publication status	Published - 2011

Keywords / Materials (for Non-textual outputs)

COMBINATORIAL SYNTHESIS
CYANINE DYES
FUNCTIONALIZATION
DERIVATIVES
LIBRARY
CHEMISTRY
DESIGN
PROBE
BORON

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10.1039/c1cc11774b

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title = "Solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor",

abstract = "The diversification of the BODIPY scaffold has been hindered by its controversial adaptability to solid-phase chemistry. Herein we report the first solid-phase synthesis of a BODIPY library in high purities. We screened the library against a set of proteins, identified an immunoglobulin fluorescent sensor (Ig Orange) and confirmed its binding by SPR experiments.",

keywords = "COMBINATORIAL SYNTHESIS, CYANINE DYES, FUNCTIONALIZATION, DERIVATIVES, LIBRARY, CHEMISTRY, DESIGN, PROBE, BORON",

author = "Marc Vendrell and Krishna, \{Gaddamanugu Gopi\} and Ghosh, \{Krishna Kanta\} and Duanting Zhai and Jun-Seok Lee and Qing Zhu and Yau, \{Yin Hoe\} and Shochat, \{Susana Geifman\} and Hyori Kim and Junho Chung and Young-Tae Chang",

year = "2011",

doi = "10.1039/c1cc11774b",

language = "English",

volume = "47",

pages = "8424--8426",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "29",

}

TY - JOUR

T1 - Solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor

AU - Vendrell, Marc

AU - Krishna, Gaddamanugu Gopi

AU - Ghosh, Krishna Kanta

AU - Zhai, Duanting

AU - Lee, Jun-Seok

AU - Zhu, Qing

AU - Yau, Yin Hoe

AU - Shochat, Susana Geifman

AU - Kim, Hyori

AU - Chung, Junho

AU - Chang, Young-Tae

PY - 2011

Y1 - 2011

N2 - The diversification of the BODIPY scaffold has been hindered by its controversial adaptability to solid-phase chemistry. Herein we report the first solid-phase synthesis of a BODIPY library in high purities. We screened the library against a set of proteins, identified an immunoglobulin fluorescent sensor (Ig Orange) and confirmed its binding by SPR experiments.

AB - The diversification of the BODIPY scaffold has been hindered by its controversial adaptability to solid-phase chemistry. Herein we report the first solid-phase synthesis of a BODIPY library in high purities. We screened the library against a set of proteins, identified an immunoglobulin fluorescent sensor (Ig Orange) and confirmed its binding by SPR experiments.

KW - COMBINATORIAL SYNTHESIS

KW - CYANINE DYES

KW - FUNCTIONALIZATION

KW - DERIVATIVES

KW - LIBRARY

KW - CHEMISTRY

KW - DESIGN

KW - PROBE

KW - BORON

U2 - 10.1039/c1cc11774b

DO - 10.1039/c1cc11774b

M3 - Article

SN - 1359-7345

VL - 47

SP - 8424

EP - 8426

JO - Chemical Communications

JF - Chemical Communications

IS - 29

ER -

Solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor

Abstract

Keywords / Materials (for Non-textual outputs)

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