Soluble Fc gamma receptors

W H Fridman, J L Teillaud, C Bouchard, C Teillaud, A Astier, E Tartour, J Galon, C Mathiot, C Sautès

Research output: Contribution to journalArticlepeer-review

Abstract

Soluble Fc gamma receptors have been identified in biological fluids of mice and humans. They are produced either by alternative splicing of the exon encoding the transmembrane region of the receptor (Fc gamma RII) or by proteolytic cleavage at the cell membrane (Fc gamma RII and Fc gamma RIII). They inhibit B cell proliferation and immunoglobulin production. Their concentrations in plasma seem to be modified during the development of certain diseases, as for instance in multiple myeloma, where plasma concentrations of soluble Fc gamma RIII are correlated with the stage of the disease.
Original languageEnglish
Pages (from-to)504-12
Number of pages9
JournalJournal of Leukocyte Biology
Volume54
Issue number5
Publication statusPublished - 1993

Keywords

  • Animals
  • Humans
  • Mice
  • Receptors, IgG
  • Solubility

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