Soluble forms of tau are toxic in Alzheimer's disease

Katherine J Kopeikina, Bradley T Hyman, Tara L Spires-Jones

Research output: Contribution to journalArticlepeer-review

Abstract

Accumulation of neurofibrillary tangles (NFT), intracellular inclusions of fibrillar forms of tau, is a hallmark of Alzheimer Disease. NFT have been considered causative of neuronal death, however, recent evidence challenges this idea. Other species of tau, such as soluble misfolded, hyperphosphorylated, and mislocalized forms, are now being implicated as toxic. Here we review the data supporting soluble tau as toxic to neurons and synapses in the brain and the implications of these data for development of therapeutic strategies for Alzheimer's disease and other tauopathies.
Original languageEnglish
Pages (from-to)223-233
Number of pages11
JournalTranslational neuroscience
Volume3
Issue number3
DOIs
Publication statusPublished - Sep 2012

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