Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia

Andrea Caporali; Marco Meloni; Ashley M Miller; Klemens Vierlinger; Alessandro Cardinali; Gaia Spinetti; Audrey Nailor; Ezio Faglia; Sergio Losa; Ambra Gotti; Orazio Fortunato; Tijana Mitic; Manuela Hofner; Christa Noehammer; Paolo Madeddu; Costanza Emanueli

doi:10.1161/ATVBAHA.112.300497

Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia

Andrea Caporali, Marco Meloni, Ashley M Miller, Klemens Vierlinger, Alessandro Cardinali, Gaia Spinetti, Audrey Nailor, Ezio Faglia, Sergio Losa, Ambra Gotti, Orazio Fortunato, Tijana Mitic, Manuela Hofner, Christa Noehammer, Paolo Madeddu, Costanza Emanueli

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The p75 neurotrophin receptor (p75(NTR)) contributes to diabetes mellitus-induced defective postischemic neovascularization. The interleukin-33 receptor ST2 is expressed as transmembrane (ST2L) and soluble (sST2) isoforms. Here, we studied the following: (1) the impact of p75(NTR) in the healing of ischemic and diabetic calf wounds; (2) the link between p75(NTR) and ST2; and (3) circulating sST2 levels in critical limb ischemia (CLI) patients.

Original language	English
Pages (from-to)	e149-60
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	32
Issue number	12
DOIs	https://doi.org/10.1161/ATVBAHA.112.300497
Publication status	Published - Dec 2012

Keywords / Materials (for Non-textual outputs)

Activating Transcription Factor 2
Aged
Aged, 80 and over
Animals
Biological Markers
Cells, Cultured
Diabetes Complications
Diabetes Mellitus
Diabetes Mellitus, Experimental
Disease Models, Animal
Endothelium, Vascular
Female
Humans
Ischemia
Lower Extremity
Male
Mice
Mice, Knockout
Middle Aged
Nerve Tissue Proteins
Predictive Value of Tests
Receptors, Cell Surface
Receptors, Interleukin
Receptors, Nerve Growth Factor
Streptozocin
Wound Healing
p38 Mitogen-Activated Protein Kinases

Access to Document

10.1161/ATVBAHA.112.300497

Soluble ST2 Is Regulated by p75 Neurotrophin Receptor and Predicts Mortality in Diabetic Patients With Critical Limb Ischemia
© 2012 American Heart Association, Inc.
Accepted author manuscript, 2.63 MB

http://atvb.ahajournals.org/content/32/12/e149

Inter-cellular trafficking and regulation of microRNA-503 expression in diabetes induced microvascular complications
Caporali, A.
UK-based charities
1/09/13 → 28/02/17
Project: Research

Cite this

Caporali, A., Meloni, M., Miller, A. M., Vierlinger, K., Cardinali, A., Spinetti, G., Nailor, A., Faglia, E., Losa, S., Gotti, A., Fortunato, O., Mitic, T., Hofner, M., Noehammer, C., Madeddu, P., & Emanueli, C. (2012). Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(12), e149-60. https://doi.org/10.1161/ATVBAHA.112.300497

@article{a5c40d0a422b49da8d87200e9a8b3f0b,

title = "Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia",

abstract = "The p75 neurotrophin receptor (p75(NTR)) contributes to diabetes mellitus-induced defective postischemic neovascularization. The interleukin-33 receptor ST2 is expressed as transmembrane (ST2L) and soluble (sST2) isoforms. Here, we studied the following: (1) the impact of p75(NTR) in the healing of ischemic and diabetic calf wounds; (2) the link between p75(NTR) and ST2; and (3) circulating sST2 levels in critical limb ischemia (CLI) patients.",

keywords = "Activating Transcription Factor 2, Aged, Aged, 80 and over, Animals, Biological Markers, Cells, Cultured, Diabetes Complications, Diabetes Mellitus, Diabetes Mellitus, Experimental, Disease Models, Animal, Endothelium, Vascular, Female, Humans, Ischemia, Lower Extremity, Male, Mice, Mice, Knockout, Middle Aged, Nerve Tissue Proteins, Predictive Value of Tests, Receptors, Cell Surface, Receptors, Interleukin, Receptors, Nerve Growth Factor, Streptozocin, Wound Healing, p38 Mitogen-Activated Protein Kinases",

author = "Andrea Caporali and Marco Meloni and Miller, {Ashley M} and Klemens Vierlinger and Alessandro Cardinali and Gaia Spinetti and Audrey Nailor and Ezio Faglia and Sergio Losa and Ambra Gotti and Orazio Fortunato and Tijana Mitic and Manuela Hofner and Christa Noehammer and Paolo Madeddu and Costanza Emanueli",

year = "2012",

month = dec,

doi = "10.1161/ATVBAHA.112.300497",

language = "English",

volume = "32",

pages = "e149--60",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1079-5642",

publisher = "Lippincott Williams & Wilkins",

number = "12",

}

Caporali, A, Meloni, M, Miller, AM, Vierlinger, K, Cardinali, A, Spinetti, G, Nailor, A, Faglia, E, Losa, S, Gotti, A, Fortunato, O, Mitic, T, Hofner, M, Noehammer, C, Madeddu, P & Emanueli, C 2012, 'Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, no. 12, pp. e149-60. https://doi.org/10.1161/ATVBAHA.112.300497

TY - JOUR

T1 - Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia

AU - Caporali, Andrea

AU - Meloni, Marco

AU - Miller, Ashley M

AU - Vierlinger, Klemens

AU - Cardinali, Alessandro

AU - Spinetti, Gaia

AU - Nailor, Audrey

AU - Faglia, Ezio

AU - Losa, Sergio

AU - Gotti, Ambra

AU - Fortunato, Orazio

AU - Mitic, Tijana

AU - Hofner, Manuela

AU - Noehammer, Christa

AU - Madeddu, Paolo

AU - Emanueli, Costanza

PY - 2012/12

Y1 - 2012/12

N2 - The p75 neurotrophin receptor (p75(NTR)) contributes to diabetes mellitus-induced defective postischemic neovascularization. The interleukin-33 receptor ST2 is expressed as transmembrane (ST2L) and soluble (sST2) isoforms. Here, we studied the following: (1) the impact of p75(NTR) in the healing of ischemic and diabetic calf wounds; (2) the link between p75(NTR) and ST2; and (3) circulating sST2 levels in critical limb ischemia (CLI) patients.

AB - The p75 neurotrophin receptor (p75(NTR)) contributes to diabetes mellitus-induced defective postischemic neovascularization. The interleukin-33 receptor ST2 is expressed as transmembrane (ST2L) and soluble (sST2) isoforms. Here, we studied the following: (1) the impact of p75(NTR) in the healing of ischemic and diabetic calf wounds; (2) the link between p75(NTR) and ST2; and (3) circulating sST2 levels in critical limb ischemia (CLI) patients.

KW - Activating Transcription Factor 2

KW - Aged

KW - Aged, 80 and over

KW - Animals

KW - Biological Markers

KW - Cells, Cultured

KW - Diabetes Complications

KW - Diabetes Mellitus

KW - Diabetes Mellitus, Experimental

KW - Disease Models, Animal

KW - Endothelium, Vascular

KW - Female

KW - Humans

KW - Ischemia

KW - Lower Extremity

KW - Male

KW - Mice

KW - Mice, Knockout

KW - Middle Aged

KW - Nerve Tissue Proteins

KW - Predictive Value of Tests

KW - Receptors, Cell Surface

KW - Receptors, Interleukin

KW - Receptors, Nerve Growth Factor

KW - Streptozocin

KW - Wound Healing

KW - p38 Mitogen-Activated Protein Kinases

U2 - 10.1161/ATVBAHA.112.300497

DO - 10.1161/ATVBAHA.112.300497

M3 - Article

C2 - 23065828

SN - 1079-5642

VL - 32

SP - e149-60

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 12

ER -

Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

Inter-cellular trafficking and regulation of microRNA-503 expression in diabetes induced microvascular complications

Cite this