Soluble tumour necrosis factor receptor-1 (sTNFR1) levels are positively associated with exercise intensity in athletes after strenuous off-road cycling

G. A. Pussieldi, E. C. Gomes, C. E. Veneroso, J. A. De Paz, T. R. Fonseca, T. T. Mendes, A. G. Rossi, M. M. Teixeira, A. L. Teixeira, A. L. Alessandri*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Aim. Strenuous exercise can enhance plasma levels of pro- and anti-inflammatory cytokines. Increases in plasma tumor necrosis factor-alpha (TNF-alpha) are followed rapidly by a rise in its natural inhibitors, soluble TNF receptors (sTNERs). These inhibitors likely prevent an over-response to the cytokine. Aims of the present study were: 1) analyze plasma sTNER1 at different time-points in response to a strenuous off-road cycling competition; 2) evaluate whether plasma levels of sTNER1 correlate to increased blood lactate levels on completion of the exercise.

Methods. Eight trained off-road cyclists took part in this study and the data collection occurred during an official off-road race. Blood samples were collected pre-race, immediately post-race, and 1 h, 2 h and 24 h during the recovery period, for plasma sTNER1 and blood lactate determination.

Results. Increase in sTNER1 plasma levels were observed immediately post-race, 1 h and 2 h post-race (P

Conclusion. An off-road cycling race stimulated an increase in plasma sTNFR1 and this anti-inflammatory molecule was positively correlated to blood lactate concentration. This result reinforces the view that exercise intensity influences the increase in plasma anti-inflammatory molecules.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalJournal of Sports Medicine and Physical Fitness
Volume54
Issue number2
Publication statusPublished - Apr 2014

Keywords

  • Cytokines
  • Physical exercise
  • Inflammation
  • IMMUNE FUNCTION
  • ALPHA PRODUCTION
  • PLASMA
  • HUMANS
  • IL-6
  • INTERLEUKIN-6
  • DETERMINANTS
  • PERFORMANCE
  • RESPONSES
  • ENDURANCE

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