Aim. Strenuous exercise can enhance plasma levels of pro- and anti-inflammatory cytokines. Increases in plasma tumor necrosis factor-alpha (TNF-alpha) are followed rapidly by a rise in its natural inhibitors, soluble TNF receptors (sTNERs). These inhibitors likely prevent an over-response to the cytokine. Aims of the present study were: 1) analyze plasma sTNER1 at different time-points in response to a strenuous off-road cycling competition; 2) evaluate whether plasma levels of sTNER1 correlate to increased blood lactate levels on completion of the exercise.
Methods. Eight trained off-road cyclists took part in this study and the data collection occurred during an official off-road race. Blood samples were collected pre-race, immediately post-race, and 1 h, 2 h and 24 h during the recovery period, for plasma sTNER1 and blood lactate determination.
Results. Increase in sTNER1 plasma levels were observed immediately post-race, 1 h and 2 h post-race (P
Conclusion. An off-road cycling race stimulated an increase in plasma sTNFR1 and this anti-inflammatory molecule was positively correlated to blood lactate concentration. This result reinforces the view that exercise intensity influences the increase in plasma anti-inflammatory molecules.
|Number of pages||7|
|Journal||Journal of Sports Medicine and Physical Fitness|
|Publication status||Published - Apr 2014|
- Physical exercise
- IMMUNE FUNCTION
- ALPHA PRODUCTION