Somatic cell nuclear transfer

I Wilmut, N Beaujean, P A de Sousa, A Dinnyes, T J King, L A Paterson, D N Wells, L E Young

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.

Original languageEnglish
Pages (from-to)583-6
Number of pages4
JournalNature
Volume419
Issue number6907
DOIs
Publication statusPublished - 10 Oct 2002

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Cattle
  • Cell Cycle
  • Cell Differentiation
  • Cloning, Organism
  • Embryonic and Fetal Development
  • Fetal Death
  • Forecasting
  • Gene Expression Regulation, Developmental
  • Goats
  • Mice
  • Nuclear Transfer Techniques
  • Oocytes
  • Ploidies
  • Sheep
  • Swine

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