Somato-dendritic secretion of neuropeptides

Colin H. Brown, Mike Ludwig, Javier E Stern

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract / Description of output

In addition to classical neurosecretion at the synapse, many neurons also secrete neurotransmitters from their cell bodies and dendrites. In contrast to synaptic transmission, somato-dendritic secretion is best characterized as modulating the overall excitability of the target cells over a longer time course via actions at presynaptic and extrasynaptic receptors. Magnocellular neurons of the hypothalamic supraoptic and paraventricular nuclei synthesize the neuropeptides, vasopressin and oxytocin, and were among the first neurons shown to secrete neurotransmitters from their cell bodies and dendrites by exocytosis. These neuropeptides modulate the activity of the neurons from which they are secreted, as well as the activity of neighboring neurons, to provide intra- and interpopulation signals that coordinate the endocrine and autonomic responses for control of cardiovascular and reproductive physiology, as well as behavior.
Original languageEnglish
Title of host publicationNeurosecretion
Subtitle of host publicationSecretory Mechanisms
EditorsJosé R. Lemos, Govindan Dayanithi
ISBN (Electronic)9783030229894
ISBN (Print)9783030229887, 9783030229917
Publication statusPublished - 1 Apr 2020

Publication series

NameMasterclass in Neuroendocrinology
ISSN (Print)2662-2068
ISSN (Electronic)2662-2076


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