Some thoughts about what non-mammalian jawed vertebrates are telling us about antigen processing and peptide-loading of MHC molecules

Rebecca Martin, Jim Kaufman

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

The major histocompatibility complex (MHC) of mammals encodes highly polymorphic classical class I and class II molecules with crucial roles in immune responses, as well as various non-classical molecules encoded by the MHC and elsewhere in the genome that have a variety of functions. These MHC molecules are supported by antigen processing and peptide loading pathways which are well-understood in mammals. This review considers what has been learned about the MHC, MHC molecules and the supporting pathways in non-mammalian jawed vertebrates. From the initial understanding from work with the chicken MHC, a great deal of diversity in the structure and function has found. Are there underlying principles?
Original languageEnglish
Article number102218
Number of pages9
JournalCurrent Opinion in Immunology
Volume77
Early online date7 Jun 2022
DOIs
Publication statusPublished - 1 Aug 2022

Keywords / Materials (for Non-textual outputs)

  • co-evolution
  • promiscuous
  • fastidious
  • generalist
  • specialist
  • single dominantly-expressed class I
  • TAP
  • tapasin

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