Some thoughts about what non-mammalian jawed vertebrates are telling us about antigen processing and peptide-loading of MHC molecules

Rebecca Martin, Jim Kaufman

Research output: Contribution to journalArticlepeer-review

Abstract

The major histocompatibility complex (MHC) of mammals encodes highly polymorphic classical class I and class II molecules with crucial roles in immune responses, as well as various non-classical molecules encoded by the MHC and elsewhere in the genome that have a variety of functions. These MHC molecules are supported by antigen processing and peptide loading pathways which are well-understood in mammals. This review considers what has been learned about the MHC, MHC molecules and the supporting pathways in non-mammalian jawed vertebrates. From the initial understanding from work with the chicken MHC, a great deal of diversity in the structure and function has found. Are there underlying principles?
Original languageEnglish
JournalCurrent Opinion in Immunology
Publication statusAccepted/In press - 10 May 2022

Keywords

  • co-evolution
  • promiscuous
  • fastidious
  • generalist
  • specialist
  • single dominantly-expressed class I
  • TAP
  • tapasin

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